6-Oxo Boldione

Base Information

• Chemical Name: 6-Oxo Boldione
• CAS No.: 72648-46-5
• Molecular Formula: C₁₉H₂₂O₃
• Molecular Weight: 298.382
• Mol file: 72648-46-5.mol

Synonyms:FCE24204

Chemical Property of 6-Oxo Boldione

Chemical Property:

• Vapor Pressure: 5.45E-09mmHg at 25°C
• Melting Point: >196°C (dec.)
• Boiling Point: 469.6°Cat760mmHg
• Flash Point: 203.3°C
• PSA: 51.21000
• Density: 1.21g/cm³
• LogP: 3.04240
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Very Slightly, Heated)

Purity/Quality:

99% ^*data from raw suppliers

6-OxoBoldione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A derivative of Exemestane (E957000), a new aromatase inhibitor. A derivative of Exemestane (E957000)

Technology Process of 6-Oxo Boldione

There total 8 articles about 6-Oxo Boldione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

17-(ethylenedioxy)-Δ4-3,6-androstenedione (174507-19-8) → Androsta-1,4-dien-3,6,17-trion (72648-46-5) + 17-(ethylenedioxy)-Δ1,4-3,6-androstenedione (206532-40-3)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; for 72h; Heating;

Reference yield: 21.0%

6β-hydroxymethylandrosta-1,4-diene-3,17-dione (121021-51-0) → Androsta-1,4-dien-3,6,17-trion (72648-46-5)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; for 0.666667h;

Reference yield: 15.0%

Androsta-1,4-diene-3,17-dione (897-06-3) → Androsta-1,4-dien-3,6,17-trion (72648-46-5)

Guidance literature:

With air; potassium tert-butylate; In tert-butyl alcohol; for 8h; Ambient temperature;

DOI:10.1016/0039-128X(93)90029-M

upstream raw materials:

Androsta-1,4-diene-3,17-dione

17-(ethylenedioxy)-Δ⁴-3,6-androstenedione

6β-hydroxymethylandrosta-1,4-diene-3,17-dione

1α,3-dipyrrolidinylandrosta-3,5-dien-17-one

Refernces

• 1、 Goelitzer,Bonnekessel,Jones,Palusczak,Hartmann. "Derivatives of exemestane - Synthesis and evaluation of aromatase inhibition". . p. 575 - 581. Retrieved 2007/10/03.
• 2、 Buzzetti,Di Salle,Longo,Briatico. "Synthesis and aromatase inhibition by potential metabolites of exemestane (6-methylenandrosta-1,4-diene-3,17-dione)". . p. 527 - 532. Retrieved 2007/10/02.