methyl N-acetylphenylalanyltyrosinate

Base Information

• Chemical Name: methyl N-acetylphenylalanyltyrosinate
• CAS No.: 15852-46-7
• Molecular Formula: C21H24 N2 O5
• Molecular Weight: 384.4257
• Mol file: 15852-46-7.mol

Synonyms:Tyrosine,N-(N-acetyl-3-phenyl-L-alanyl)-, methyl ester, L- (8CI);N-Acetyl-L-phenylalanyl-L-tyrosine methyl ester; NSC 337571

Chemical Property of methyl N-acetylphenylalanyltyrosinate

Chemical Property:

• Vapor Pressure: 8.5E-20mmHg at 25°C
• Boiling Point: 692.1°C at 760 mmHg
• Flash Point: 372.4°C
• Density: 1.228g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl N-acetylphenylalanyltyrosinate

There total 3 articles about methyl N-acetylphenylalanyltyrosinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

(S)-2-acetylamino-3-phenylpropanoic acid (2018-61-3) + L-tyrosine methyl ester HCl (3417-91-2) → N-acetyl-L-phenylalanyl-L-tyrosine methyl ester (15852-46-7)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1039/c4ob01577k

Reference yield:

L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) → N-acetyl-L-phenylalanyl-L-tyrosine methyl ester (15852-46-7)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 0 - 20 °C

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

With thionyl chloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1039/c4ob01577k

Reference yield:

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → N-acetyl-L-phenylalanyl-L-tyrosine methyl ester (15852-46-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / water / 2 h / 0 - 20 °C

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

With sodium hydrogencarbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In water; N,N-dimethyl-formamide;

DOI:10.1039/c4ob01577k

upstream raw materials:

(S)-2-acetylamino-3-phenylpropanoic acid

L-tyrosine methyl ester HCl

L-tyrosine

L-phenylalanine

Downstream raw materials:

N-acetyl-L-tyrosine methyl ester

methyl (S)-2-acetamido-3-(4-acetoxyphenyl)propanoate

3-(4-acetoxy-3-nitrophenyl)-2-acetylaminopropionic acid methyl ester