2-Pentofuranosyl-2h-indazole

Base Information

• Chemical Name: 2-Pentofuranosyl-2h-indazole
• CAS No.: 28083-97-8
• Molecular Formula: C₁₂H₁₄N₂O₄
• Molecular Weight: 250.254
• NSC Number: 128672
• DSSTox Substance ID: DTXSID80950812
• Mol file: 28083-97-8.mol

Synonyms:2-pentofuranosyl-2h-indazole;28083-97-8;NSC128672;DTXSID80950812;NSC-128672

Chemical Property of 2-Pentofuranosyl-2h-indazole

Chemical Property:

• Vapor Pressure: 2.21E-13mmHg at 25°C
• Boiling Point: 560.1°Cat760mmHg
• Flash Point: 292.5°C
• Density: 1.62g/cm³
• XLogP3: 0
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 250.09535693
• Heavy Atom Count: 18
• Complexity: 304

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=CN(N=C2C=C1)C3C(C(C(O3)CO)O)O

Technology Process of 2-Pentofuranosyl-2h-indazole

There total 7 articles about 2-Pentofuranosyl-2h-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2,3,5-tris-O-(p-chlorobenzoyl)-D-ribofuranoside → 2-(β-D-ribofuranosyl)indazole (28083-97-8,54503-63-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 81.3 percent / conc. H₂SO₄ / acetic acid / 2 h / Ambient temperature

2: 36.4 percent / p-toluenesulfonic acid / 0.17 h / 160 °C / 20 Torr

3: NaOMe, MeOH / Ambient temperature

With methanol; sulfuric acid; sodium methylate; toluene-4-sulfonic acid; In acetic acid;

DOI:10.1021/jm00102a006

Reference yield:

2-(2,3,5-tris-O-(p-chlorobenzoyl)-β-D-ribofuranosyl)indazole (1053636-92-2) → 2-(β-D-ribofuranosyl)indazole (28083-97-8,54503-63-8)

Guidance literature:

With methanol; sodium methylate; Ambient temperature;

DOI:10.1021/jm00102a006

Reference yield:

benzimidazole (271-44-3) → 2-(β-D-ribofuranosyl)indazole (28083-97-8,54503-63-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 36.4 percent / p-toluenesulfonic acid / 0.17 h / 160 °C / 20 Torr

2: NaOMe, MeOH / Ambient temperature

With methanol; sodium methylate; toluene-4-sulfonic acid;

DOI:10.1021/jm00102a006

upstream raw materials:

2-(2,3,5-tris-O-(p-chlorobenzoyl)-β-D-ribofuranosyl)indazole

benzimidazole

1,2,3,5-tetraacetylribose

1-O-acetyl-2,3,5-tris-O-(p-chlorobenzoyl)-β-D-ribofuranose

Refernces

• 1、 Sagi,Szucs,Vereb,Otvos. "Synthesis and enzymatic activity of some new purine ring system analogues of adenosine 3',5'-cyclic monophosphate". . p. 4549 - 4556. Retrieved 2007/10/02.