7-beta-ribofuranosylguanine

Base Information

• Chemical Name: 7-beta-ribofuranosylguanine
• CAS No.: 15373-27-0
• Molecular Formula: C10H13 N5 O5
• Molecular Weight: 283.244
• Mol file: 15373-27-0.mol

Synonyms:Guanine,7-b-D-ribofuranosyl- (8CI); 7-b-D-Ribofuranosylguanine; NSC116092

Chemical Property of 7-beta-ribofuranosylguanine

Chemical Property:

• Vapor Pressure: 2.44E-25mmHg at 25°C
• Boiling Point: 775.9°C at 760 mmHg
• PKA: 9.78±0.20(Predicted)
• Flash Point: 423.1°C
• PSA: 159.51000
• Density: 2.25g/cm³
• LogP: -2.10550

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-beta-ribofuranosylguanine

There total 7 articles about 7-beta-ribofuranosylguanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Phosphoric acid (2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-purin-7-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester (2R,3S,4R,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-4-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yl ester → N7-(β-D-Ribofuranosyl)guanin (15373-27-0) + cytidine 2',3'-cyclic monophosphate (633-90-9)

Guidance literature:

With zinc(II) nitrate; sodium nitrate; HEPES buffer; In water; at 90.1 ℃; Rate constant;

DOI:10.1080/07328319608002466

Reference yield:

adenylyl-(3'-5')-guanosine → N7-(β-D-Ribofuranosyl)guanin (15373-27-0) + adenosine monophosphate (84-21-9)

Guidance literature:

With ammonium acetate buffer; Calf spleen phosphodiesterase; In water; at 37 ℃; for 24h;

Reference yield:

2'-deoxyadenylyl-(3'-5')-guanosine → N7-(β-D-Ribofuranosyl)guanin (15373-27-0) + adenosine monophosphate (84-21-9)

Guidance literature:

With ammonium acetate buffer; Calf spleen phosphodiesterase; In water; at 37 ℃; for 24h;

upstream raw materials:

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

N-(6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide

Downstream raw materials:

N²-isobutyryl-7-<5-O-(4,4'-dimethoxytrityl)-2-deoxy-β-D-erythro-pentofuranosyl>guanine

Refernces

• 1、 Bookser, Brett C.,Raffaele, Nicholas B.. "High-throughput five minute microwave accelerated glycosylation approach to the synthesis of nucleoside libraries". . p. 173 - 179. Retrieved 2007/10/03.