N-Acetylsulfamethazine

Base Information

• Chemical Name: N-Acetylsulfamethazine
• CAS No.: 35255-37-9
• Molecular Formula: C₁₄H₁₆N₄O₃S
• Molecular Weight: 320.372
• Hs Code.: 2933599090
• DSSTox Substance ID: DTXSID00188751
• Nikkaji Number: J3.042.362C
• Wikidata: Q83060590
• Mol file: 35255-37-9.mol

Synonyms:N-acetylsulfadimidine;N-acetylsulfamethazine

Chemical Property of N-Acetylsulfamethazine

Chemical Property:

• Vapor Pressure: 3.7E-12mmHg at 25°C
• Boiling Point: 550.3°Cat760mmHg
• Flash Point: 286.6°C
• PSA: 114.63000
• Density: 1.38g/cm³
• LogP: 3.07940
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated)
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 320.09431156
• Heavy Atom Count: 22
• Complexity: 487

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC(=N1)N(C(=O)C)S(=O)(=O)C2=CC=C(C=C2)N)C
• Uses: The main metabolite of Sulfamethazine.

Technology Process of N-Acetylsulfamethazine

There total 4 articles about N-Acetylsulfamethazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(4,6-dimethyl-pyrimidin-2-yl)-N-(4-nitro-benzenesulfonyl)-acetamide (106379-60-6) → N-(4,6-dimethyl-pyrimidin-2-yl)-N-sulfanilyl-acetamide (35255-37-9)

Guidance literature:

With palladium on activated charcoal; acetic acid; Hydrogenation;

Reference yield:

{4-[acetyl-(4,6-dimethyl-pyrimidin-2-yl)-sulfamoyl]-phenyl}-carbamic acid benzyl ester (102314-41-0) → N-(4,6-dimethyl-pyrimidin-2-yl)-N-sulfanilyl-acetamide (35255-37-9)

Guidance literature:

With palladium on activated charcoal; acetic acid; Hydrogenation;

Reference yield:

N-(4,6-dimethyl-pyrimidin-2-yl)-4-nitro-benzenesulfonamide (153312-38-0) → N-(4,6-dimethyl-pyrimidin-2-yl)-N-sulfanilyl-acetamide (35255-37-9)

Guidance literature:

Multi-step reaction with 2 steps

2: palladium/charcoal; acetic acid / Hydrogenation

With palladium on activated charcoal; acetic acid;

upstream raw materials:

N-(4,6-dimethyl-pyrimidin-2-yl)-N-(4-nitro-benzenesulfonyl)-acetamide

{4-[acetyl-(4,6-dimethyl-pyrimidin-2-yl)-sulfamoyl]-phenyl}-carbamic acid benzyl ester

N-(4,6-dimethyl-pyrimidin-2-yl)-4-nitro-benzenesulfonamide

[4-(4,6-dimethyl-pyrimidin-2-ylsulfamoyl)-phenyl]-carbamic acid benzyl ester