Dichlorisone

Base Information

Chemical Name:Dichlorisone
CAS No.:7008-26-6
Molecular Formula:C21H26 Cl2 O4
Molecular Weight:413.341
Hs Code.:
European Community (EC) Number:230-283-8
UNII:AMW2MRV3OT
DSSTox Substance ID:DTXSID10220353
NCI Thesaurus Code:C77002
Nikkaji Number:J8.880C
Wikidata:Q27274011
Wikipedia:Dichlorisone
Mol file:7008-26-6.mol

Synonyms:DICHLORISONE;7008-26-6;Dichlorisone [INN];AMW2MRV3OT;Dichlorisone (INN);(8S,9R,10S,11S,13S,14S,17R)-9,11-dichloro-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one;Dichlorisonum;Diclorisona;UNII-AMW2MRV3OT;Dichlorisonum [INN-Latin];Diclorisona [INN-Spanish];EINECS 230-283-8;DICHLORISONE [MI];SCHEMBL81297;DTXSID10220353;CZJXBZPJABCCRQ-BULBTXNYSA-N;NS00037004;D07814;Q27274011;9,11beta-Dichloro-17,21-dihydroxypregna-1,4-diene-3,20-dione;(11beta)-9,11-Dichloro-17,21-dihydroxypregna-1,4-diene-3,20-dione;9.ALPHA.,11.BETA.-DICHLORO-17.ALPHA.,21-DIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE

Suppliers and Price of Dichlorisone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Dichlorisone
250mg
$ 1390.00

TRC
Dichlorisone
25mg
$ 180.00

Total 3 raw suppliers

Chemical Property of Dichlorisone

Chemical Property:

Vapor Pressure:3.42E-16mmHg at 25°C
Melting Point:238-241 °C (decomp)(Solv: acetone (67-64-1))
Boiling Point:586.4°C at 760 mmHg
PKA:11.99±0.70(Predicted)
Flash Point:308.4°C
PSA：74.60000
Density:1.37g/cm³
LogP:3.16550
XLogP3:3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:412.1208147
Heavy Atom Count:27
Complexity:776

Purity/Quality:

98%Min ^*data from raw suppliers

Dichlorisone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC12CC(C3(C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC43C)Cl)Cl
Isomeric SMILES:C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@@]43C)Cl)Cl
Uses Dichlorisone is a 9α,11β-dichloro corticoid. Dichlorisone has anti-antiinflammatory potency. Dichlorisone could be modifed to be used as glucocorticoid receptor agonists as well as a P-glycoprotein inhibitor.

Technology Process of Dichlorisone

There total 4 articles about Dichlorisone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-61-8
dichlorisone 21-acetate

: 7008-26-6
Dichlorisone

Guidance literature:: With perchloric acid;
DOI:10.1021/ja01518a045

Reference yield:

: 4380-55-6
pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 21-acetate

: 7008-26-6
Dichlorisone

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; THF; LiCl; HCl

2: methanol.HClO₄

With tetrahydrofuran; hydrogenchloride; perchloric acid; acetic acid; lithium chloride;
DOI:10.1021/ja01518a045