Acetamide, N-(2-(4-bromobenzoyl)-8,9-dihydro-5,8,8-trimethyl-6H-furo(2,3-b)pyrano(4,3-d)pyridin-1-yl)-2,2,2-trichloro-

Base Information

Chemical Name:Acetamide, N-(2-(4-bromobenzoyl)-8,9-dihydro-5,8,8-trimethyl-6H-furo(2,3-b)pyrano(4,3-d)pyridin-1-yl)-2,2,2-trichloro-
CAS No.:172985-38-5
Molecular Formula:C22H18BrCl3N2O4
Molecular Weight:560.6523
Hs Code.:
DSSTox Substance ID:DTXSID50169479
Wikidata:Q83039190
Mol file:172985-38-5.mol

Synonyms:172985-38-5;Acetamide, N-(2-(4-bromobenzoyl)-8,9-dihydro-5,8,8-trimethyl-6H-furo(2,3-b)pyrano(4,3-d)pyridin-1-yl)-2,2,2-trichloro-;C22H18BrCl3N2O4;DTXSID50169479;C22-H18-Br-Cl3-N2-O4;LS-8311

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Acetamide, N-(2-(4-bromobenzoyl)-8,9-dihydro-5,8,8-trimethyl-6H-furo(2,3-b)pyrano(4,3-d)pyridin-1-yl)-2,2,2-trichloro-

Chemical Property:

Vapor Pressure:1.87E-17mmHg at 25°C
Boiling Point:663.1°Cat760mmHg
Flash Point:354.8°C
Density:1.585g/cm³
XLogP3:6.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:557.95155
Heavy Atom Count:32
Complexity:741

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C2COC(CC2=C3C(=C(OC3=N1)C(=O)C4=CC=C(C=C4)Br)NC(=O)C(Cl)(Cl)Cl)(C)C

Technology Process of Acetamide, N-(2-(4-bromobenzoyl)-8,9-dihydro-5,8,8-trimethyl-6H-furo(2,3-b)pyrano(4,3-d)pyridin-1-yl)-2,2,2-trichloro-

There total 2 articles about Acetamide, N-(2-(4-bromobenzoyl)-8,9-dihydro-5,8,8-trimethyl-6H-furo(2,3-b)pyrano(4,3-d)pyridin-1-yl)-2,2,2-trichloro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.8%

: 172985-16-9
(1-Amino-5,8,8-trimethyl-8,9-dihydro-6H-3,7-dioxa-4-aza-cyclopenta[a]naphthalen-2-yl)-(4-bromo-phenyl)-methanone

: 76-02-8
trifluoroacetyl chloride

: 172985-38-5
N-[2-(4-Bromo-benzoyl)-5,8,8-trimethyl-8,9-dihydro-6H-3,7-dioxa-4-aza-cyclopenta[a]naphthalen-1-yl]-2,2,2-trichloro-acetamide

Guidance literature:: In 1,4-dioxane; Heating;
DOI:10.1007/BF02219066

Reference yield:

: 6-[2-(4-Bromo-phenyl)-2-oxo-ethoxy]-3,3,8-trimethyl-3,4-dihydro-1H-pyrano[3,4-c]pyridine-5-carbonitrile

: 172985-38-5
N-[2-(4-Bromo-benzoyl)-5,8,8-trimethyl-8,9-dihydro-6H-3,7-dioxa-4-aza-cyclopenta[a]naphthalen-1-yl]-2,2,2-trichloro-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 94.1 percent / NaOEt / ethanol / Heating

2: 72.8 percent / dioxane / Heating

With sodium ethanolate; In 1,4-dioxane; ethanol;
DOI:10.1007/BF02219066