Synonyms:trichloroacetyl chloride
99% *data from raw suppliers
T+,
T
T+:Very toxic;There total 67 articles about Trichloroacetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield: 85.0%
Reference yield: 63.6%
Reference yield: 20.0%
The study focuses on the facile one-pot synthesis of S-alkylthiocarbamates, a class of compounds that have significant biological effects and are useful as herbicides. The study introduces a novel two-step method utilizing trichloroacetyl chloride that is both simple and high-yielding, allowing the incorporation of a wide range of substituents. The process design is simple and uses commercially available reagents, avoiding the use of toxic substances and gaseous reagents. The chemicals used in the synthesis include trichloroacetyl chloride, various thiols (such as alkanethiols, benzyl mercaptan, and benzenethiol), and different amines (including ammonium hydroxide, primary amines, and secondary amines). The conclusions drawn from the study highlight the versatility and efficiency of the method, allowing the production of a range of thiocarbamates in high yields simply by changing the amine used in the reaction. The study also explored alternative routes and found that the traditional order of reagent addition was more successful, although it had certain limitations.
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