5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-8-(1S)-1-hydroxyethyl-1-methoxy-, (8S,10S)-

Base Information

• Chemical Name: 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-8-(1S)-1-hydroxyethyl-1-methoxy-, (8S,10S)-
• CAS No.: 28008-51-7
• Molecular Formula: C₂₁H₂₀O₈
• Molecular Weight: 400.385
• Mol file: 28008-51-7.mol

Synonyms:5,12-Naphthacenedione,7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-8-(1-hydroxyethyl)-1-methoxy-,(8S,10S)- (8CI); 5,12-Naphthacenedione,7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-8-(1-hydroxyethyl)-1-methoxy-,[8S-[8a,8(R*),10a]]-; Daunorubicinol aglycone;Dihydrodaunomycinone; Leukaemomycinone D

Chemical Property of 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-8-(1S)-1-hydroxyethyl-1-methoxy-, (8S,10S)-

Chemical Property:

• Vapor Pressure: 2.26E-19mmHg at 25°C
• Boiling Point: 679.1°C at 760 mmHg
• Flash Point: 243.1°C
• PSA: 144.52000
• Density: 1.587g/cm³
• LogP: 0.97330

Purity/Quality:

≥95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-8-(1S)-1-hydroxyethyl-1-methoxy-, (8S,10S)-

There total 7 articles about 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-8-(1S)-1-hydroxyethyl-1-methoxy-, (8S,10S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(+)-Daunomycinone (21794-55-8) → (1'S)-dihydrodaunomycinone (28008-51-7)

Guidance literature:

With pH 7.0 buffer; NADP; manganese(ll) chloride; DL-isocitric acid trisodium salt; In N,N-dimethyl-formamide; for 26h; Ambient temperature; isocitric dehydrogenase;

DOI:10.1021/jo00295a052

Reference yield:

daunomycinol (28008-55-1) → (1'S)-dihydrodaunomycinone (28008-51-7)

Guidance literature:

With hydrogenchloride; at 100 ℃; for 0.5h;

DOI:10.1021/jo00295a052

Reference yield:

13-(R,S)-dihydrodaunorubicin → 13-dihydrodaunomycinone (28008-51-7,125515-17-5,126934-36-9)

Guidance literature:

With hydrogenchloride; at 80 ℃; for 1h;

upstream raw materials:

(+)-Daunomycinone

daunomycin hydrochloride

DNR

daunomycinol