1-(2-Chloroethyl)-3-(2,6-dimethoxyphenyl)urea

Base Information

Chemical Name:1-(2-Chloroethyl)-3-(2,6-dimethoxyphenyl)urea
CAS No.:21561-22-8
Molecular Formula:C₁₁H₁₅ClN₂O₃
Molecular Weight:258.705
Hs Code.:
NSC Number:162330
UNII:KTU7K422BH
DSSTox Substance ID:DTXSID10175899
Nikkaji Number:J59.428H
Wikidata:Q83046232
Mol file:21561-22-8.mol

Synonyms:1-(2-Chloroethyl)-3-(2,6-dimethoxyphenyl)urea;21561-22-8;KTU7K422BH;Urea, 1-(2-chloroethyl)-3-(2,6-dimethoxyphenyl)-;NSC-162330;NSC162330;NSC 162330;UNII-KTU7K422BH;DTXSID10175899;N-(2-CHLOROETHYL)-N'-(2,6-DIMETHOXYPHENYL)UREA;UREA, N-(2-CHLOROETHYL)-N'-(2,6-DIMETHOXYPHENYL)-

Suppliers and Price of 1-(2-Chloroethyl)-3-(2,6-dimethoxyphenyl)urea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 1-(2-Chloroethyl)-3-(2,6-dimethoxyphenyl)urea

Chemical Property:

Vapor Pressure:7.93E-06mmHg at 25°C
Boiling Point:375.2°C at 760 mmHg
Flash Point:180.7°C
Density:1.248g/cm³
XLogP3:1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:258.0771200
Heavy Atom Count:17
Complexity:229

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C(=CC=C1)OC)NC(=O)NCCCl

Technology Process of 1-(2-Chloroethyl)-3-(2,6-dimethoxyphenyl)urea

There total 1 articles about 1-(2-Chloroethyl)-3-(2,6-dimethoxyphenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1943-83-5
2-chloroethyl isothiocyanate

: 2734-70-5
2,6-dimethoxyaniline

: 21561-22-8
1-(2-chloro-ethyl)-3-(2,6-dimethoxy-phenyl)-urea

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1021/jm991121g

Reference yield:

: 21561-22-8
1-(2-chloro-ethyl)-3-(2,6-dimethoxy-phenyl)-urea

: 306968-19-4
1-(2,6-dimethoxy-phenyl)-imidazolidin-2-one

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 0.5h; Heating;
DOI:10.1021/jm991121g

Reference yield:

: 21561-22-8
1-(2-chloro-ethyl)-3-(2,6-dimethoxy-phenyl)-urea

: 1-{2-[1-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-piperidin-4-yl]-ethyl}-3-(2,6-dimethoxy-phenyl)-imidazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: NaH / tetrahydrofuran / 0.5 h / Heating

2: 20 percent / NaH / N,N-dimethyl-acetamide / 4 h / 100 °C

With sodium hydride; In tetrahydrofuran; N,N-dimethyl acetamide; 1: Cyclization / 2: Substitution;
DOI:10.1021/jm991121g