N-(butan-2-yl)-4-methylbenzamide

Base Information

• Chemical Name: N-(butan-2-yl)-4-methylbenzamide
• CAS No.: 16409-28-2
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.273
• Mol file: 16409-28-2.mol

Synonyms:p-Toluamide,N-sec-butyl- (8CI); NSC 21799

Chemical Property of N-(butan-2-yl)-4-methylbenzamide

Chemical Property:

• Vapor Pressure: 0.000198mmHg at 25°C
• Boiling Point: 327.8°Cat760mmHg
• Flash Point: 195.1°C
• Density: 0.976g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(butan-2-yl)-4-methylbenzamide

There total 4 articles about N-(butan-2-yl)-4-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-methyl-benzaldehyde (104-87-0) + iso-butanol (78-92-2,15892-23-6) → N-sec-butyl-4-methylbenzamide (16409-28-2)

Guidance literature:

4-methyl-benzaldehyde; With sodium azide; trifluorormethanesulfonic acid; acetic acid; at 40 ℃;

iso-butanol; With trifluorormethanesulfonic acid; at 90 ℃;

DOI:10.1016/j.tetlet.2016.08.069

Reference yield: 72.0%

SEC-BUTYLAMINE (33966-50-6) + N,4-dimethyl-N-tosylbenzamide → N-sec-butyl-4-methylbenzamide (16409-28-2)

Guidance literature:

In tetrahydrofuran; at 120 ℃; for 12h;

DOI:10.3762/bjoc.11.138

Reference yield:

SEC-BUTYLAMINE (33966-50-6) + para-bromotoluene (106-38-7) → N-sec-butyl-4-methylbenzamide (16409-28-2)

Guidance literature:

With sodium carbonate; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); In water; at 170 ℃; for 0.166667h; microwave irradiation;

DOI:10.1021/ol0512031

upstream raw materials:

SEC-BUTYLAMINE

para-bromotoluene

N-methyl-p-methylbenzamide

4-methyl-benzaldehyde

Refernces

• 1、 Asahara, Haruyasu,Arikiyo, Keita,Nishiwaki, Nagatoshi. "Development of variously functionalized nitrile oxides". . p. 1241 - 1245. Retrieved 2015/08/18.