N-METHYL-P-TOLUAMIDE

Base Information

• Chemical Name: N-METHYL-P-TOLUAMIDE
• CAS No.: 18370-11-1
• Molecular Formula: C9H11NO
• Molecular Weight: 149.192
• Hs Code.: 2924299090
• Mol file: 18370-11-1.mol

Synonyms:p-Toluamide,N-methyl- (6CI,8CI);N,4-Dimethylbenzamide;N-Methyl-p-toluamide;

Chemical Property of N-METHYL-P-TOLUAMIDE

Chemical Property:

• Vapor Pressure: 0.00175mmHg at 25°C
• Refractive Index: 1.524
• Boiling Point: 293.2 °C at 760 mmHg
• Flash Point: 168.3 °C
• PSA: 29.10000
• Density: 1.021 g/cm³
• LogP: 1.74550

Purity/Quality:

99% ^*data from raw suppliers

N-Methyl-p-toluamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-METHYL-P-TOLUAMIDE

There total 53 articles about N-METHYL-P-TOLUAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-methyl-benzoyl chloride (874-60-2) + methylamine (74-89-5) → N-methyl-p-methylbenzamide (18370-11-1)

Guidance literature:

With sodium hydroxide; In water; for 0.25h;

DOI:10.1039/P29860001211

Reference yield: 95.0%

methanol (67-56-1) + para-methylbenzonitrile (104-85-8) → N-methyl-p-methylbenzamide (18370-11-1)

Guidance literature:

With tris(2-diphenylphosphinoethyl)phosphine; potassium tert-butylate; water; caesium carbonate; cobalt(II) bromide; In m-xylene; at 140 ℃; for 30h; Green chemistry;

DOI:10.1021/acscatal.9b03916

Reference yield: 95.0%

p-Toluic acid (99-94-5) + methylamine (74-89-5) → N-methyl-p-methylbenzamide (18370-11-1)

Guidance literature:

p-Toluic acid; With thionyl chloride; at 80 ℃; for 2h;

methylamine; In dichloromethane; at 20 ℃; Further stages.;

DOI:10.1002/ejoc.200200586

upstream raw materials:

4-methyl-benzoyl chloride

methylamine

p-toluimidic acid methyl ester

methyl iodide

Downstream raw materials:

N-methyl-3-nitro-4-methylbenzamide

3-methyl-4,6-dioxo-5-phenyl-2-p-tolyl-5,6-dihydro-4H-[1,3]oxazinium betaine

5-benzyl-3-methyl-4,6-dioxo-2-p-tolyl-5,6-dihydro-4H-[1,3]oxazinium betaine

4,N-dimethyl-benzimidoyl chloride