2-Chloro-N-(2,6-dichlorophenyl)acetamide

Base Information

• Chemical Name: 2-Chloro-N-(2,6-dichlorophenyl)acetamide
• CAS No.: 3644-56-2
• Molecular Formula: C8H6 Cl3 N O
• Molecular Weight: 238.501
• Hs Code.: 2924299090
• European Community (EC) Number: 222-874-4
• DSSTox Substance ID: DTXSID20189962
• Nikkaji Number: J205.563E
• Wikidata: Q83062194
• Mol file: 3644-56-2.mol

Synonyms:2-Chloro-N-(2,6-dichlorophenyl)acetamide;3644-56-2;EINECS 222-874-4;MFCD00044773;N-(2,6-dichlorophenyl)-2-chloroacetamide;SCHEMBL7291906;DTXSID20189962;Acetanilide, 2,2',6'-trichloro-;AB3530;STK397271;AKOS000268706;N-(2,6-Dichlorophenyl)chloroacetamide;AS-44718;2-Chloro-N-(2,6-dichlorophenyl)-acetamide;BB 0253165;CS-0309196;EN300-16884;2-CHLORO-N-(2,6-DICHLORO-PHENYL)-ACETAMIDE;Z56812706;F1252-0975

Chemical Property of 2-Chloro-N-(2,6-dichlorophenyl)acetamide

Chemical Property:

• Vapor Pressure: 7.36E-06mmHg at 25°C
• Melting Point: 176-179℃
• Boiling Point: 376.2°Cat760mmHg
• Flash Point: 181.3°C
• PSA: 29.10000
• Density: 1.511g/cm³
• LogP: 3.24370
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 236.951497
• Heavy Atom Count: 13
• Complexity: 178

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-N-(2,6-dichlorophenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: R34:Causes burns.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S28A:After contact wit

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C(=C1)Cl)NC(=O)CCl)Cl

Technology Process of 2-Chloro-N-(2,6-dichlorophenyl)acetamide

There total 2 articles about 2-Chloro-N-(2,6-dichlorophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.5%

chloroacetyl chloride (79-04-9) + 2,6-Dichloroaniline (608-31-1) → 2-chloro-N-(2,6-dichlorophenyl)acetamide (3644-56-2)

Guidance literature:

With magnesium oxide; In chloroform; for 2h; Heating;

DOI:10.1002/jhet.5570270708

Reference yield: 78.0%

→ 2-chloro-N-(2,6-dichlorophenyl)acetamide (3644-56-2)

Guidance literature:

With potassium carbonate; In acetone; at 0 ℃; for 0.5h;

In acetone; at 20 ℃;

Reference yield: 90.0%

2-chloro-N-(2,6-dichlorophenyl)acetamide (3644-56-2) + 7-(diphenylmethylene)octahydro-2H-pyrido<1,2-a>pyrazine (146367-41-1) → N-(2,6-dichlorophenyl)-7-(diphenylmethylene)octahydro-2H-pyrido<1,2-a>pyrazine-2-acetamide

Guidance literature:

With potassium carbonate; potassium iodide; In acetone;

DOI:10.1021/jo00055a023

upstream raw materials:

chloroacetyl chloride

2,6-Dichloroaniline

Downstream raw materials:

N,N-dimethyl-glycine-(2,6-dichloro-anilide)

N-tert-butyl-glycine 2,6-dichloro-anilide

Piperidinoessigsaeure-<2,6-dichlor-anilid>

N-(2,6-Dichloro-phenyl)-2-(5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanyl)-acetamide

Refernces

• 1、 El-Shershaby, Mohamed H.,El-Gamal, Kamal M.,Bayoumi, Ashraf H.,El-Adl, Khaled,Ahmed, Hany E. A.,Abulkhair, Hamada S.. "Synthesis, antimicrobial evaluation, DNA gyrase inhibition, and in silico pharmacokinetic studies of novel quinoline derivatives". . . Retrieved 2020/10/22.
• 2、 Mohammadi-Khanaposhtani, Maryam,Nikraftar, Atefeh,Asgari, Mohammad Sadegh,Emadi, Mehdi,Mojtabavi, Somayeh,Faramarzi, Mohammad Ali,Rastegar, Hossein,Larijani, Bagher,Mahdavi, Mohammad. "Synthesis, in vitro and in silico enzymatic inhibition assays, and toxicity evaluations of new 4,5-diphenylimidazole-N-phenylacetamide derivatives as potent α-glucosidase inhibitors". . p. 1273 - 1283. Retrieved 2021/05/26.