9-((Phenylmethyl)amino)-6-(trifluoromethyl)-1,2,3,4-tetrahydro-1-acridinol

Base Information

Chemical Name:9-((Phenylmethyl)amino)-6-(trifluoromethyl)-1,2,3,4-tetrahydro-1-acridinol
CAS No.:104628-22-0
Molecular Formula:C₂₁H₁₉F₃N₂O
Molecular Weight:372.39
Hs Code.:
DSSTox Substance ID:DTXSID00909069
ChEMBL ID:CHEMBL50410
Mol file:104628-22-0.mol

Synonyms:9-((Phenylmethyl)amino)-6-(trifluoromethyl)-1,2,3,4-tetrahydro-1-acridinol;1-Acridinol, 1,2,3,4-tetrahydro-9-((phenylmethyl)amino)-6-(trifluoromethyl)-;104628-22-0;CHEMBL50410;BDBM9384;SCHEMBL9875512;C21H19F3N2O;DTXSID00909069;9-(benzylamino)-6-(trifluoromethyl)-1,2,3,4-tetrahydroacridin-1-ol;9-Amino-1 ,2,3,4-tetrahydroacridin-1-ol deriv. 1ll;9-Benzylamino-6-trifluoromethyl-1,2,3,4-tetrahydroacridin-1-ol;9-(Benzylimino)-6-(trifluoromethyl)-1,2,3,4,9,10-hexahydroacridin-1-ol

Suppliers and Price of 9-((Phenylmethyl)amino)-6-(trifluoromethyl)-1,2,3,4-tetrahydro-1-acridinol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9-((Phenylmethyl)amino)-6-(trifluoromethyl)-1,2,3,4-tetrahydro-1-acridinol

Chemical Property:

Vapor Pressure:1.53E-11mmHg at 25°C
Boiling Point:517.7°Cat760mmHg
Flash Point:266.9°C
Density:1.357g/cm³
XLogP3:4.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:372.14494772
Heavy Atom Count:27
Complexity:494

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(C2=C(C3=C(C=C(C=C3)C(F)(F)F)N=C2C1)NCC4=CC=CC=C4)O

Technology Process of 9-((Phenylmethyl)amino)-6-(trifluoromethyl)-1,2,3,4-tetrahydro-1-acridinol

There total 6 articles about 9-((Phenylmethyl)amino)-6-(trifluoromethyl)-1,2,3,4-tetrahydro-1-acridinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 104586-69-8
9-benzylamino-3,4-dihydro-6-trifluoromethylacridin-1(2H)-one

: 104628-22-0
9-benzylamino-1,2,3,4-tetrahydro-6-trifluoromethylacridin-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; for 2h;
DOI:10.1021/jm00128a024

Reference yield:

: 1483-54-1
2-amino-4-trifluoromethylbenzonitrile

: 104628-22-0
9-benzylamino-1,2,3,4-tetrahydro-6-trifluoromethylacridin-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / p-toluenesulfonic acid monohydrate / toluene / 2 h / Heating

2: 38 percent / K₂CO₃ / CuCl / tetrahydrofuran / 5 h / Heating

3: 58 percent / NaOH / 4N>4> / CH₂Cl₂; H₂O / 4 h

4: 57 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 2 h

With sodium hydroxide; lithium aluminium tetrahydride; potassium carbonate; toluene-4-sulfonic acid; tetra(n-butyl)ammonium hydrogensulfate; copper(l) chloride; In tetrahydrofuran; diethyl ether; dichloromethane; water; toluene;
DOI:10.1021/jm00128a024

Reference yield:

: 100-39-0
benzyl bromide

: 104628-22-0
9-benzylamino-1,2,3,4-tetrahydro-6-trifluoromethylacridin-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / NaOH / 4N>4> / CH₂Cl₂; H₂O / 4 h

2: 57 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 2 h

With sodium hydroxide; lithium aluminium tetrahydride; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1021/jm00128a024