Technology Process of Halichondrin B
There total 4 articles about Halichondrin B which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trimethylsilyl trifluoromethanesulfonate;
In
dichloromethane;
at -78 ℃;
for 0.25h;
DOI:10.1002/anie.201705523
- Guidance literature:
-
C90H158O20Si5;
With
tetrabutyl ammonium fluoride; Trimethylacetic acid;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at 20 ℃;
for 4h;
With
calcium carbonate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at 20 ℃;
for 2h;
With
pyridinium p-toluenesulfonate;
In
dichloromethane;
at 20 ℃;
for 4h;
- Guidance literature:
-
With
2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; methanol;
at 23 ℃;
for 3h;
Inert atmosphere;
DOI:10.1021/jacs.1c05270