2-Thienylpyrrole

Base Information

• Chemical Name: 2-Thienylpyrrole
• CAS No.: 52707-46-7
• Molecular Formula: C8H7NS
• Molecular Weight: 149.216
• Hs Code.: 2934999090
• Mol file: 52707-46-7.mol

Synonyms:2-(2-Thienyl)-1H-pyrrole;2-(2-Thienyl)pyrrole;2-(2'-Thienyl)pyrrole;

Chemical Property of 2-Thienylpyrrole

Chemical Property:

• Vapor Pressure: 0.00168mmHg at 25°C
• Melting Point: 78-80 °C
• Refractive Index: 1.631
• Boiling Point: 303.3 °C at 760 mmHg
• PKA: 17.09±0.50(Predicted)
• Flash Point: 140.3 °C
• PSA: 44.03000
• Density: 1.217 g/cm³
• LogP: 2.74320

Purity/Quality:

99%, ^*data from raw suppliers

2-(2-THIENYL)PYRROLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Thienylpyrrole

There total 26 articles about 2-Thienylpyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-thiophen-2-yl-1H-3-carboxylic acid ethyl ester → 2-(thiophen-2-yl)-1H-pyrrole (52707-46-7)

Guidance literature:

With sodium hydroxide; In ethylene glycol; at 160 ℃; for 0.0833333h;

DOI:10.1021/ol049857h

Reference yield: 71.0%

2-bromothiophene (1003-09-4) + sodium pyrrolide (7697-45-2) → 2-(thiophen-2-yl)-1H-pyrrole (52707-46-7)

Guidance literature:

sodium pyrrolide; With zinc(II) chloride; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; johnphos; In tetrahydrofuran; at 20 ℃; for 0.166667h; Inert atmosphere;

2-bromothiophene; In tetrahydrofuran; at 100 ℃; for 17h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b02056

Reference yield: 61.5%

3-(1,3-dioxolan-2-yl)-1-(2-thienyl)-1-propanone (145654-80-4) → 2-(thiophen-2-yl)-1H-pyrrole (52707-46-7) + 2,4-bis(2-thienyl)-1H-indole (145654-81-5)

Guidance literature:

With ammonium acetate; acetic anhydride; acetic acid; Heating;

DOI:10.1016/S0040-4020(01)92285-9

upstream raw materials:

2-acetylthiophene oxime

acetylene

1,2-dichloro-ethane

O-(2-vinyl) methyl 2-thienyl ketoxime

Downstream raw materials:

4,4-difluoro-8-(4’-bromophenyl)-3,5-dithiophenyl-4-bora-3α,4α-diaza-s-indacene

Refernces

• 1、 Trofimov,B.A. et al.. "-". . . Retrieved 1977.
• 2、 Marzo, Leyre,Ghosh, Indrajit,Esteban, Francisco,K?nig, Burkhard. "Metal-Free Photocatalyzed Cross Coupling of Bromoheteroarenes with Pyrroles". . p. 6780 - 6784. Retrieved 2016/10/14.
• 3、 Du, Wei,Zhao, Mi-Na,Ren, Zhi-Hui,Wang, Yao-Yu,Guan, Zheng-Hui. "Copper-catalyzed 5-endo-trig cyclization of ketoxime carboxylates: A facile synthesis of 2-arylpyrroles". supporting information. p. 7437 - 7439. Retrieved 2014/07/07.