1-(4-Fluorophenyl)piperazine hydrochloride

Base Information

• Chemical Name: 1-(4-Fluorophenyl)piperazine hydrochloride
• CAS No.: 16141-90-5
• Molecular Formula: C10H13 F N2 . Cl H
• Molecular Weight: 216.686
• Hs Code.: 2933599090
• DSSTox Substance ID: DTXSID90480211
• NSC Number: 149515
• Mol file: 16141-90-5.mol

Synonyms:16141-90-5;1-(4-fluorophenyl)piperazine hydrochloride;1-(4-FLUOROPHENYL)PIPERAZINE HCL;1-(4-fluorophenyl)piperazine;hydrochloride;1-(4-Fluorophenyl)piperazine hydrochloride (1:1);SCHEMBL714521;DTXSID90480211;NSC149515;AKOS022181238;NSC-149515;AS-49957;FT-0703440;O10291;Piperazine,1-(4-fluorophenyl)-,hydrochloride(1:1)

Chemical Property of 1-(4-Fluorophenyl)piperazine hydrochloride

Chemical Property:

• Vapor Pressure: 1.78E-05mmHg at 25°C
• Melting Point: 182-185 °C(Solv: ethanol (64-17-5))
• Boiling Point: 363.6 °C at 760 mmHg
• Flash Point: 137.8 °C
• PSA: 15.27000
• Density: 1.112 g/cm³
• LogP: 2.43110
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 216.0829543
• Heavy Atom Count: 14
• Complexity: 149

Purity/Quality:

98%min ^*data from raw suppliers

1-(4-fluorophenyl)piperazinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1)C2=CC=C(C=C2)F.Cl

Technology Process of 1-(4-Fluorophenyl)piperazine hydrochloride

There total 1 articles about 1-(4-Fluorophenyl)piperazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

bis-(2-chloroethyl)amine hydrochloride (821-48-7) + 4-fluoroaniline (371-40-4) → p-Fluorophenylpiperazine hydrochloride (16141-90-5)

Guidance literature:

In sulfolane; at 150 ℃; for 14h;

DOI:10.1016/j.tetlet.2015.06.003

Reference yield: 92.0%

(Z)-ethyl 2-(bromomethyl)-3-phenylacrylate (88039-49-0) + p-Fluorophenylpiperazine hydrochloride (16141-90-5) → ethyl (E)-2-((4-(4-fluorophenyl)piperazin-1-yl)methyl)-3-phenylacrylate

Guidance literature:

With potassium carbonate; sodium iodide; In acetonitrile; at 25 - 30 ℃;

DOI:10.1021/acs.jmedchem.7b00643

Reference yield: 86.9%

2-(4-bromobutyl)isoindoline-1,3-dione (5394-18-3) + p-Fluorophenylpiperazine hydrochloride (16141-90-5) → 2-{4-[4-(4-fluorophenyl)piperazin-1-yl]butyl}-1H-isoindole-1,3(2H)-dione (120301-26-0)

Guidance literature:

With potassium carbonate; sodium iodide; In acetonitrile; Reflux;

DOI:10.1039/c8md00237a

upstream raw materials:

bis-(2-chloroethyl)amine hydrochloride

4-fluoroaniline

Downstream raw materials:

6-<2-<4-(4-fluorophenyl)-1-piperazinyl>ethyl>-5,6,7,8-tetrahydro-1,6-naphthyridine

6-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-5,6,7,8-tetrahydro-[1,6]naphthyridine

6-<2-<4-(4-fluorophenyl)-1-piperazinyl>ethyl>-5,6,7,8-tetrahydro-1,6-naphthyridine difumarate

6-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-5,6,7,8-tetrahydro-[1,6]naphthyridine; compound with (E)-but-2-enedioic acid

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