7,8-Epoxy-3-hydroxyestra-1,3,5(10)-trien-17-one (7alpha,8alpha)-

Base Information

• Chemical Name: 7,8-Epoxy-3-hydroxyestra-1,3,5(10)-trien-17-one (7alpha,8alpha)-
• CAS No.: 55056-56-9
• Molecular Formula: C₁₈H₂₀O₃
• Molecular Weight: 284.355
• Mol file: 55056-56-9.mol

Synonyms:7,8-Epoxy-8H-cyclopenta[a]phenanthrene,estra-1,3,5(10)-trien-17-one deriv.

Chemical Property of 7,8-Epoxy-3-hydroxyestra-1,3,5(10)-trien-17-one (7alpha,8alpha)-

Chemical Property:

• Vapor Pressure: 4.4E-10mmHg at 25°C
• Boiling Point: 486.3°C at 760 mmHg
• Flash Point: 181.8°C
• PSA: 49.83000
• Density: 1.32g/cm³
• LogP: 2.94870

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7,8-Epoxy-3-hydroxyestra-1,3,5(10)-trien-17-one (7alpha,8alpha)-

There total 6 articles about 7,8-Epoxy-3-hydroxyestra-1,3,5(10)-trien-17-one (7alpha,8alpha)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

equilin (474-86-2) → 7ξ,8ξ-epoxy-3-hydroxy-1,3,5(10)-estratrien-17-one (36070-30-1,55056-56-9)

Guidance literature:

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 1.5h;

DOI:10.1016/0039-128X(87)90015-8

Reference yield: 40.0%

Acetic acid (7R,8R,9R,13S,14R)-13-methyl-17-oxo-6,7,9,11,12,13,14,15,16,17-decahydro-20-oxa-cyclopropa[7,8]cyclopenta[a]phenanthren-3-yl ester (187025-00-9) → equilenin (517-09-9) + (7R,8R,9R,13S,14R)-3-Hydroxy-13-methyl-6,9,11,12,13,14,15,16-octahydro-7H-20-oxa-cyclopropa[7,8]cyclopenta[a]phenanthren-17-one (55056-56-9) + (8R,13S,14R)-3,8-Dihydroxy-13-methyl-8,9,11,12,13,14,15,16-octahydro-cyclopenta[a]phenanthren-17-one

Guidance literature:

With boron trifluoride diethyl etherate; In methanol; for 24h; Ambient temperature;

Reference yield: 1.0%

Acetic acid (7R,8R,9R,13S,14R)-13-methyl-17-oxo-6,7,9,11,12,13,14,15,16,17-decahydro-20-oxa-cyclopropa[7,8]cyclopenta[a]phenanthren-3-yl ester (187025-00-9) → equilenin (517-09-9) + (7R,8R,9R,13S,14R)-3-Hydroxy-13-methyl-6,9,11,12,13,14,15,16-octahydro-7H-20-oxa-cyclopropa[7,8]cyclopenta[a]phenanthren-17-one (55056-56-9)

Guidance literature:

With oxalic acid; In methanol; Ambient temperature;

upstream raw materials:

equilin

Acetic acid (7R,8R,9R,13S,14R)-13-methyl-17-oxo-6,7,9,11,12,13,14,15,16,17-decahydro-20-oxa-cyclopropa[7,8]cyclopenta[a]phenanthren-3-yl ester

estra-1,3,5⁽¹⁰⁾,7-tetraene-17-one-3-acetate