474-86-2 Usage
Uses
Used in Hormone Replacement Therapy:
EQUILIN is used as a hormone replacement therapy for individuals experiencing menopausal symptoms or those with hormonal imbalances. It helps alleviate symptoms such as hot flashes, night sweats, and vaginal dryness, as well as preventing bone loss and reducing the risk of osteoporosis.
Used in Pharmaceutical Industry:
EQUILIN is used in the pharmaceutical industry for the development of drugs and medications that target estrogen receptors. Its presence in Premarin makes it a valuable component in the formulation of hormone replacement therapies and other estrogen-related treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 474-86-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,7 and 4 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 474-86:
(5*4)+(4*7)+(3*4)+(2*8)+(1*6)=82
82 % 10 = 2
So 474-86-2 is a valid CAS Registry Number.
InChI:InChI=1/C18H20O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3-5,10,14,16,19H,2,6-9H2,1H3/t14?,16?,18-/m0/s1
474-86-2Relevant academic research and scientific papers
Method for synthesizing equilin
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Paragraph 0014; 0022, (2021/05/26)
The invention relates to a synthesis method of a steroid drug, namely equilin. The method comprises the following steps: starting from estrone, performing phenolic hydroxyl group and C17-position ketal protection, and then performing oxidation and further dehydrogenation to obtain an intermediate II; reducing and deoxidizing the intermediate II to obtain an intermediate III; and finally, performing deprotection to obtain a final product, namely an equilin bulk drug. The method is few in steps and comprises four conversion steps; total yield is as high as 50%; the used raw materials are relatively cheap and easy to obtain; the whole process route is green and safe; and the bulk drug is high in quality, has purity of 99.8% or above, and is suitable for industrial production.
