2-CHLORO-N-1-NAPHTHYLPROPANAMIDE

Base Information

• Chemical Name: 2-CHLORO-N-1-NAPHTHYLPROPANAMIDE
• CAS No.: 22302-58-5
• Molecular Formula: C13H12 Cl N O
• Molecular Weight: 233.697
• Hs Code.: 2924299090
• Mol file: 22302-58-5.mol

Synonyms:Propionamide,2-chloro-N-1-naphthyl- (8CI)

Chemical Property of 2-CHLORO-N-1-NAPHTHYLPROPANAMIDE

Chemical Property:

• Vapor Pressure: 5.41E-08mmHg at 25°C
• Boiling Point: 441.5°Cat760mmHg
• Flash Point: 220.8°C
• PSA: 29.10000
• Density: 1.263g/cm³
• LogP: 3.47860

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-N-1-naphthylpropanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-N-1-NAPHTHYLPROPANAMIDE

There total 2 articles about 2-CHLORO-N-1-NAPHTHYLPROPANAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-chloropropionyl chloride (7623-09-8) + 1-amino-naphthalene (134-32-7) → 2-chloro-N-(naphthalen-1-yl)propanamide (22302-58-5)

Guidance literature:

With potassium carbonate; In acetone; at 0 - 20 ℃; for 4h;

DOI:10.1016/j.ejmech.2021.113879

Reference yield:

→ 2-chloro-N-(naphthalen-1-yl)propanamide (22302-58-5)

Guidance literature:

/BRN= 386133/, Bzl., CH3-CHCl-COCl; nach Schotten-Baumann;

Reference yield: 82.0%

4-benzylpyperidine (31252-42-3) + 2-chloro-N-(naphthalen-1-yl)propanamide (22302-58-5) → 2-(4-benzylpiperidin-1-yl)-N-(naphthalen-1-yl)propanamide

Guidance literature:

With potassium carbonate; In acetonitrile; at 75 ℃; for 8h;

DOI:10.1016/j.ejmech.2021.113879

upstream raw materials:

2-chloropropionyl chloride

1-amino-naphthalene

Refernces

• 1、 Chen, Yin,Hao, Chao,Liu, Bi-Feng,Liu, Xin,Ma, Ru,Ma, Yurong,Xiong, Jiaying,Xu, Junyi,Ye, Jiaqi,Zhang, Guisen,Zhang, Shuang,Zhuang, Tao. "Optimization of bifunctional piperidinamide derivatives as σ1R Antagonists/MOR agonists for treating neuropathic pain". . . Retrieved 2021/10/12.