2-AMINO-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID (4-METHOXY-PHENYL)-AMIDE

Base Information

• Chemical Name: 2-AMINO-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID (4-METHOXY-PHENYL)-AMIDE
• CAS No.: 83822-33-7
• Molecular Formula: C16H18N2O2S
• Molecular Weight: 302.397
• Hs Code.: 2934999090
• Mol file: 83822-33-7.mol

Synonyms:2-Amino-N-(4-methoxyphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide;2-Amino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid (4-methoxy-phenyl)-amide;Arboxylic acid (4-methoxy-phenyl)-amide;(2-Amino(4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl))-N-(4-methoxyphenyl)carboxamide;

Chemical Property of 2-AMINO-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID (4-METHOXY-PHENYL)-AMIDE

Chemical Property:

• Vapor Pressure: 6.98E-09mmHg at 25°C
• Refractive Index: 1.676
• Boiling Point: 466.6 °C at 760 mmHg
• Flash Point: 236 °C
• PSA: 92.59000
• Density: 1.309 g/cm³
• LogP: 4.12420

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-N-(4-methoxyphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID (4-METHOXY-PHENYL)-AMIDE

There total 4 articles about 2-AMINO-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID (4-METHOXY-PHENYL)-AMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-cyano-N-(4-methoxyphenyl)acetamide (5382-38-7) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 2-amino-N-(4-methoxyphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide (83822-33-7)

Guidance literature:

With sulfur; barium aluminate; In ethanol; water; at 80 ℃; for 14h; Green chemistry;

DOI:10.1080/10426507.2017.1295961

Reference yield: 65.0%

2-Cyano-2-cyclohexylidene-N-(4-methoxy-phenyl)-acetamide (89733-18-6) → 2-amino-N-(4-methoxyphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide (83822-33-7)

Guidance literature:

With diethylamine; In ethanol; at 50 ℃; for 3h;

Reference yield:

2-cyano-N-(4-methoxyphenyl)acetamide (5382-38-7) → 2-amino-N-(4-methoxyphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide (83822-33-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 33 percent / CH₃COONH₄, CH₃COOH / benzene / 6 h / Heating

2: 65 percent / S, Et₂NH / ethanol / 3 h / 50 °C

With ammonium acetate; acetic acid; diethylamine; In ethanol; benzene;

upstream raw materials:

2-Cyano-2-cyclohexylidene-N-(4-methoxy-phenyl)-acetamide

2-cyano-N-(4-methoxyphenyl)acetamide

4-methoxy-aniline

cyclohexanone

Downstream raw materials:

N-[3-(4-Methoxy-phenylcarbamoyl)-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl]-oxalamic acid ethyl ester

3-(4-Methoxy-phenyl)-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one

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