S-benzoyl-3-mercapto-2-methylpropanoyl chloride

Base Information

• Chemical Name: S-benzoyl-3-mercapto-2-methylpropanoyl chloride
• CAS No.: 74654-91-4
• Molecular Formula: C11H11 Cl O2 S
• Molecular Weight: 242.726
• Hs Code.: 2930909090
• Mol file: 74654-91-4.mol

Synonyms:Benzenecarbothioicacid, S-(3-chloro-2-methyl-3-oxopropyl) ester, (R)-

Chemical Property of S-benzoyl-3-mercapto-2-methylpropanoyl chloride

Chemical Property:

• Vapor Pressure: 0.000215mmHg at 25°C
• Boiling Point: 326.5°C at 760 mmHg
• Flash Point: 151.2°C
• PSA: 59.44000
• Density: 1.255g/cm³
• LogP: 2.96150

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of S-benzoyl-3-mercapto-2-methylpropanoyl chloride

There total 4 articles about S-benzoyl-3-mercapto-2-methylpropanoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-3-(benzoylthio)-2-methylpropionic acid (72679-02-8) → 3-(benzoylthio)-2(S)-methylpropionyl chloride (74654-91-4)

Guidance literature:

With pyridine; thionyl chloride; for 7h; Ambient temperature;

DOI:10.1021/jm00357a014

Reference yield:

(R)-3-Benzoylsulfanyl-2-methyl-propionic acid (74407-70-8) → 3-(benzoylthio)-2(S)-methylpropionyl chloride (74654-91-4)

Guidance literature:

With thionyl chloride;

DOI:10.1248/cpb.31.570

Reference yield:

(D)-3-(Benzoylthio)-2-methylpropanoic acid (74431-50-8) → 3-(benzoylthio)-2(S)-methylpropionyl chloride (74654-91-4)

Guidance literature:

Multi-step reaction with 2 steps

2: thionyl chloride

With thionyl chloride;

DOI:10.1248/cpb.31.570

upstream raw materials:

(R)-3-Benzoylsulfanyl-2-methyl-propionic acid

(2S)-3-(benzoylthio)-2-methylpropionic acid

(D)-3-(Benzoylthio)-2-methylpropanoic acid

Downstream raw materials:

1-<(S)-3-(benzoylthio)-2-methyl-1-oxopropyl>indoline-2-carboxylic acid

(+)-(S)-1-<(R)-(3-benzoylthio)-2-methyl-1-oxopropyl>indoline-2-carboxylic acid

ethyl 1-<3-(benzoylthio)-2(S)-methylpropionyl>indoline-2(S)-carboxylate

ethyl 1-<3-(benzoylthio)-2(S)-methylpropionyl>indoline-2(R)-carboxylate