6-Fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1-vinyl-1,8-naphthyridine-3-carboxylic acid

Base Information

Chemical Name:6-Fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1-vinyl-1,8-naphthyridine-3-carboxylic acid
CAS No.:74274-71-8
Molecular Formula:C₁₅H₁₅FN₄O₃
Molecular Weight:318.308
Hs Code.:
DSSTox Substance ID:DTXSID10225287
Wikidata:Q83104220
ChEMBL ID:CHEMBL42877
Mol file:74274-71-8.mol

Synonyms:74274-71-8;6-Fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1-vinyl-1,8-naphthyridine-3-carboxylic acid;1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-1-ethenyl-6-fluoro-4-oxo-7-(1-piperazinyl)-;1,4-Dihydro-1-ethenyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid;CHEMBL42877;SCHEMBL10521403;C15H15FN4O3;DTXSID10225287;VNHOPSYZRNBBLV-UHFFFAOYSA-N;LS-95941

Suppliers and Price of 6-Fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1-vinyl-1,8-naphthyridine-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
6-FLUORO-1,4-DIHYDRO-4-OXO-7-(1-PIPERAZINYL)-1-VINYL-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID 95.00%
5MG
$ 498.88

Total 0 raw suppliers

Chemical Property of 6-Fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1-vinyl-1,8-naphthyridine-3-carboxylic acid

Chemical Property:

Vapor Pressure:6.88E-14mmHg at 25°C
Boiling Point:571.2°C at 760 mmHg
Flash Point:299.3°C
PSA：87.46000
Density:1.487g/cm³
LogP:1.13770
XLogP3:-0.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:3
Exact Mass:318.11281852
Heavy Atom Count:23
Complexity:547

Purity/Quality:: 6-FLUORO-1,4-DIHYDRO-4-OXO-7-(1-PIPERAZINYL)-1-VINYL-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C=CN1C=C(C(=O)C2=CC(=C(N=C21)N3CCNCC3)F)C(=O)O

Technology Process of 6-Fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1-vinyl-1,8-naphthyridine-3-carboxylic acid

There total 5 articles about 6-Fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1-vinyl-1,8-naphthyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.4%

: 87939-17-1
7-(4-acetyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-1-vinyl-1,8-naphthyridine-3-carboxylic acid

: 84424-27-1
6-fluoro-1,4-dihydro-7-hydroxy-4-oxo-1-vinyl-1,8-naphthyridine-3-carboxylic acid

: 74274-71-8
6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1-vinyl-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: With sodium hydroxide; for 2h; Heating;
DOI:10.1021/jm00369a011

Reference yield:

: 75167-15-6
7-(4-ethoxycarbonyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-1-vinyl-1,8-naphthyridine-3-carboxylic acid

: 74274-71-8
6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1-vinyl-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: With sodium hydroxide; In acetic acid;

Reference yield:

: 84233-60-3
ethyl 7-(4-acetyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate

: 74274-71-8
6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1-vinyl-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 92.9 percent / K₂CO₃ / dimethylformamide / 3 h / 100 °C

2: 90.3 percent / SOCl₂ / CHCl₃ / 0.5 h / Heating

3: 80.6 percent / KOH / ethanol / 2 h / Heating

4: 82.4 percent / 10percent NaOH / 2 h / Heating

With potassium hydroxide; sodium hydroxide; thionyl chloride; potassium carbonate; In ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00369a011