1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-6-fluoro-7-(4-methyl-1-piperazinyl)-1-vinyl-4-oxo-

Base Information

Chemical Name:1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-6-fluoro-7-(4-methyl-1-piperazinyl)-1-vinyl-4-oxo-
CAS No.:74274-72-9
Molecular Formula:C₁₆H₁₇FN₄O₃
Molecular Weight:332.334
Hs Code.:
DSSTox Substance ID:DTXSID70225288
Wikidata:Q83104221
ChEMBL ID:CHEMBL102466

Synonyms:BRN 6235291;74274-72-9;1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-6-fluoro-7-(4-methyl-1-piperazinyl)-1-vinyl-4-oxo-;CHEMBL102466;C16H17FN4O3;DTXSID70225288;LS-95953

Suppliers and Price of 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-6-fluoro-7-(4-methyl-1-piperazinyl)-1-vinyl-4-oxo-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-6-fluoro-7-(4-methyl-1-piperazinyl)-1-vinyl-4-oxo-

Chemical Property:

Vapor Pressure:1.57E-12mmHg at 25°C
Boiling Point:540.8°Cat760mmHg
Flash Point:280.9°C
Density:1.451g/cm³
XLogP3:0.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:3
Exact Mass:332.12846858
Heavy Atom Count:24
Complexity:574

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCN(CC1)C2=C(C=C3C(=O)C(=CN(C3=N2)C=C)C(=O)O)F

Technology Process of 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-6-fluoro-7-(4-methyl-1-piperazinyl)-1-vinyl-4-oxo-

There total 5 articles about 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-6-fluoro-7-(4-methyl-1-piperazinyl)-1-vinyl-4-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.6%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 74274-71-8
6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1-vinyl-1,8-naphthyridine-3-carboxylic acid

: 74274-72-9
6-Fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1-vinyl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid

Guidance literature:: With formic acid; In water; at 120 - 125 ℃; for 17h;
DOI:10.1021/jm00369a011

Reference yield:

: 84233-60-3
ethyl 7-(4-acetyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate

: 74274-72-9
6-Fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1-vinyl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 92.9 percent / K₂CO₃ / dimethylformamide / 3 h / 100 °C

2: 90.3 percent / SOCl₂ / CHCl₃ / 0.5 h / Heating

3: 80.6 percent / KOH / ethanol / 2 h / Heating

4: 82.4 percent / 10percent NaOH / 2 h / Heating

5: 43.6 percent / HCO₂H / H₂O / 17 h / 120 - 125 °C

With potassium hydroxide; sodium hydroxide; formic acid; thionyl chloride; potassium carbonate; In ethanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00369a011

Reference yield:

: 87939-15-9
ethyl 7-(4-acetyl-1-piperazinyl)-1-(2-chloroethyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate

: 74274-72-9
6-Fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1-vinyl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 80.6 percent / KOH / ethanol / 2 h / Heating

2: 82.4 percent / 10percent NaOH / 2 h / Heating

3: 43.6 percent / HCO₂H / H₂O / 17 h / 120 - 125 °C

With potassium hydroxide; sodium hydroxide; formic acid; In ethanol; water;
DOI:10.1021/jm00369a011