trans-α-Necrodol

Base Information

Chemical Name:trans-α-Necrodol
CAS No.:104104-38-3
Molecular Formula:C₁₀H₁₈O
Molecular Weight:154.252
Hs Code.:
Mol file:104104-38-3.mol

Synonyms:2-Cyclopentene-1-methanol,3,4,5,5-tetramethyl-, (1R-trans)-; (-)-a-Necrodol; a-Necrodol

Suppliers and Price of trans-α-Necrodol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of trans-α-Necrodol

Chemical Property:

PSA：20.23000
LogP:2.21710

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of trans-α-Necrodol

There total 19 articles about trans-α-Necrodol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 127308-49-0
(3R,5R)-3-<<(tert-butyldimethylsilyl)oxy>methyl>-1,4,4,5-tetramethylcyclopentene

: 104104-38-3
(3,4,5,5-tetramethylcyclopent-2-enyl)methanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 6h; Ambient temperature;
DOI:10.1021/jo00300a021

Reference yield:

: 127308-41-2
(1S,3R,5R)-3-(hydroxymethyl)-4,4,5-trimethylcyclopentanecarboxylic acid

: 104104-38-3
(3,4,5,5-tetramethylcyclopent-2-enyl)methanol

Guidance literature:: Multi-step reaction with 8 steps

1: diethyl ether; methanol / 0.5 h / Ambient temperature

2: imidazole, 4-(dimethylamino)pyridine / tetrahydrofuran / 3 h / Ambient temperature

4: 1) m-chloroperoxybenzoic acid, 2) diisopropylamine / 1) CH₂Cl₂, -10 deg C, 0.5 h, 2) reflux, 0.5 h

5: lithium ethoxyaluminium hydride / tetrahydrofuran / 0 °C

6: Et₃N / CH₂Cl₂ / 4 h / Ambient temperature

7: Li / liquid ammonia; tetrahydrofuran; methanol / 1 h / Heating

8: tetra-n-butylammonium fluoride / tetrahydrofuran / 6 h / Ambient temperature

With 1H-imidazole; dmap; lithium monoethoxyaluminum hydride; tetrabutyl ammonium fluoride; lithium; triethylamine; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; ammonia;
DOI:10.1021/jo00300a021

Reference yield:

: 127308-42-3
(1S,3R,5R)-methyl 3-(hydroxymethyl)-4,4,5-trimethylcyclopentanecarboxylate

: 104104-38-3
(3,4,5,5-tetramethylcyclopent-2-enyl)methanol

Guidance literature:: Multi-step reaction with 7 steps

1: imidazole, 4-(dimethylamino)pyridine / tetrahydrofuran / 3 h / Ambient temperature

3: 1) m-chloroperoxybenzoic acid, 2) diisopropylamine / 1) CH₂Cl₂, -10 deg C, 0.5 h, 2) reflux, 0.5 h

4: lithium ethoxyaluminium hydride / tetrahydrofuran / 0 °C

5: Et₃N / CH₂Cl₂ / 4 h / Ambient temperature

6: Li / liquid ammonia; tetrahydrofuran; methanol / 1 h / Heating

7: tetra-n-butylammonium fluoride / tetrahydrofuran / 6 h / Ambient temperature

With 1H-imidazole; dmap; lithium monoethoxyaluminum hydride; tetrabutyl ammonium fluoride; lithium; triethylamine; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; ammonia;
DOI:10.1021/jo00300a021