necrodol

Base Information

• Chemical Name: necrodol
• CAS No.: 104086-70-6
• Molecular Formula: C10H18O
• Molecular Weight: 154.24932
• Mol file: 104086-70-6.mol

Synonyms:necrodol;(1S)-2,2,3,4-Tetramethyl-3-cyclopentene-1-methanol;(1R)-2,2,3α-Trimethyl-4-methylene-1β-cyclopentanemethanol;2,2,3α-Trimethyl-4-methylene-1β-cyclopentanemethanol

Chemical Property of necrodol

Chemical Property:

• PSA: 20.23000
• LogP: 2.21710

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of necrodol

There total 30 articles about necrodol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(-)-(1R,3R)-ethyl 2,3,3-trimethyl-4-methylidenecyclopentanecarboxylate (321156-42-7) → (-)-(1R,3R)-ethyl 2,3,3-trimethyl-4-methylidenecyclopentanemethanol (104086-70-6)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 0.5h;

DOI:10.1021/jo0013812

Reference yield: 97.0%

2,2,3-trimethyl-4-methylenecyclopentanecarboxylic acid ethyl ester → β-necrodol (104086-70-6,104113-51-1,120664-44-0,125276-85-9,125276-88-2)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 1h;

DOI:10.1021/jf904452v

Reference yield: 93.0%

(1R,3R)-2,2,3-Trimethyl-4-methylene-cyclopentanecarbaldehyde (125276-86-0) → (-)-(1R,3R)-ethyl 2,3,3-trimethyl-4-methylidenecyclopentanemethanol (104086-70-6)

Guidance literature:

With sodium hydroxide; lithium aluminium tetrahydride; water; In diethyl ether; 1.) 35 deg C, 30 min.; 2.) 0 deg C, 30 min.;

DOI:10.1002/hlca.19890720534

upstream raw materials:

(1R,3R)-2,2,3-Trimethyl-4-methylene-cyclopentanecarboxylic acid methyl ester

(1R,3R)-2,2,3-Trimethyl-4-methylene-cyclopentanecarbaldehyde

(-)-(1R,3R)-ethyl 2,3,3-trimethyl-4-methylidenecyclopentanecarboxylate

ethyl (1R,3S,4S)-4-hydroxy-2,2,3-trimethylcyclopentane carboxylate

Downstream raw materials:

(3,4,5,5-tetramethylcyclopent-2-enyl)methanol

(-)-γ-necrodol

(-)-α-epi-necrodol

Refernces

PHENYLCAMPHORIC ACID: STEREOCHEMISTRY AND EPIMERIZATION

10.1016/S0040-4039(00)81949-8

The research aimed to revise the stereochemistry of phenylcamphoric acid, a compound with a history of assigned structures and configurations since its first preparation in 1894. The researchers conducted difference NOE experiments and confirmed their new assignment through x-ray crystallography. They discovered that base treatment of methyl phenylcamphorate led to equilibration with its previously unknown epimer, methyl-epiphenylcamphorate. The study was motivated by the structural and stereochemical similarity of phenylcamphoric acid to B-necrodol, a terpenoid alcohol found in the defensive secretion of a carrion beetle, with the hope that the acid could serve as a synthetic precursor for B-necrodol.

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 104086-70-6 necrodol

Send

Send

Metric Ton KG G Pound L ML

Send

Send