Pyrido(2,3-d)pyrimidine-6-carboxylic acid, 1,4-dihydro-2-((2-(diethylamino)ethyl)thio)-7-methyl-4-oxo-1-phenyl-, ethyl ester, monohydrochloride

Base Information

• Chemical Name: Pyrido(2,3-d)pyrimidine-6-carboxylic acid, 1,4-dihydro-2-((2-(diethylamino)ethyl)thio)-7-methyl-4-oxo-1-phenyl-, ethyl ester, monohydrochloride
• CAS No.: 131511-64-3
• Molecular Formula: C23H28 N4 O3 S . Cl H
• Molecular Weight: 477.0194
• DSSTox Substance ID: DTXSID10157094
• Mol file: 131511-64-3.mol

Synonyms:Pyrido(2,3-d)pyrimidine-6-carboxylic acid, 1,4-dihydro-2-((2-(diethylamino)ethyl)thio)-7-methyl-4-oxo-1-phenyl-, ethyl ester, monohydrochloride;131511-64-3;Pyrido(2,3-d)pyrimidine-6-carboxylic acid, 2-((2-(diethylamino)ethyl)thio)-1,4-dihydro-7-methyl-4-oxo-1-phenyl-, ethyl ester, monohydrochloride;C23H28N4O3S.ClH;DTXSID10157094;C23-H28-N4-O3-S.Cl-H;LS-134079

Chemical Property of Pyrido(2,3-d)pyrimidine-6-carboxylic acid, 1,4-dihydro-2-((2-(diethylamino)ethyl)thio)-7-methyl-4-oxo-1-phenyl-, ethyl ester, monohydrochloride

Chemical Property:

• Vapor Pressure: 6.66E-14mmHg at 25°C
• Boiling Point: 590.1°Cat760mmHg
• Flash Point: 310.7°C
• Density: g/cm³
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 10
• Exact Mass: 476.1648897
• Heavy Atom Count: 32
• Complexity: 649

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)CCSC1=NC(=O)C2=CC(=C(N=C2N1C3=CC=CC=C3)C)C(=O)OCC.Cl

Technology Process of Pyrido(2,3-d)pyrimidine-6-carboxylic acid, 1,4-dihydro-2-((2-(diethylamino)ethyl)thio)-7-methyl-4-oxo-1-phenyl-, ethyl ester, monohydrochloride

There total 3 articles about Pyrido(2,3-d)pyrimidine-6-carboxylic acid, 1,4-dihydro-2-((2-(diethylamino)ethyl)thio)-7-methyl-4-oxo-1-phenyl-, ethyl ester, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(2-Diethylamino-ethylsulfanyl)-7-methyl-4-oxo-1-phenyl-1,4-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (126209-81-2) → 2-(2-Diethylamino-ethylsulfanyl)-7-methyl-4-oxo-1-phenyl-1,4-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester; hydrochloride (131511-64-3)

Guidance literature:

With hydrogenchloride; In ethanol;

Reference yield:

ethyl 7-methyl-1-phenyl-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrido<2,3-d>pyrimidine-6-carboxylate (82140-37-2) → 2-(2-Diethylamino-ethylsulfanyl)-7-methyl-4-oxo-1-phenyl-1,4-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester; hydrochloride (131511-64-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / NaOC₂H₅ / 14 h / Heating; 1.) ethanol 2.) benzene

2: 90 percent / HCl / ethanol

With hydrogenchloride; sodium ethanolate; In ethanol;

Reference yield:

2-(diethylamino)ethyl chloride (100-35-6) → 2-(2-Diethylamino-ethylsulfanyl)-7-methyl-4-oxo-1-phenyl-1,4-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester; hydrochloride (131511-64-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / NaOC₂H₅ / 14 h / Heating; 1.) ethanol 2.) benzene

2: 90 percent / HCl / ethanol

With hydrogenchloride; sodium ethanolate; In ethanol;

upstream raw materials:

2-(2-Diethylamino-ethylsulfanyl)-7-methyl-4-oxo-1-phenyl-1,4-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

ethyl 7-methyl-1-phenyl-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrido<2,3-d>pyrimidine-6-carboxylate

2-(diethylamino)ethyl chloride