100-35-6

Basic information

• Product Name: (2-CHLORO-ETHYL)-DIETHYL-AMINE
• Synonyms: N-(2-CHLORO ETHYL)DIETHYLAMINE;2-(DIETHYLAMINO)ETHYL CHLORIDE;(2-CHLORO-ETHYL)-DIETHYL-AMINE;AURORA KA-7583;2-(diethylamino)chloroethane;2-chloro-triethylamin;2-chlorotriethylamine;beta-(diethylamino)ethylchloride
• CAS NO: 100-35-6
• Molecular Formula: C₆H₁₄ClN
• Molecular Weight: 135.64
• EINECS: 202-843-1
• Mol File: 100-35-6.mol
• Article Data: 15

Chemical Properties

• Melting Point: 173-175 °C
• Boiling Point: 219.31°C (rough estimate)
• Flash Point: 22.8°C
• Appearance: /
• Density: 1.0013 (rough estimate)
• Vapor Pressure: 20.3mmHg at 25°C
• Refractive Index: 1.4530 (estimate)
• PKA: 9.37±0.25(Predicted)
• CAS DataBase Reference: (2-CHLORO-ETHYL)-DIETHYL-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-CHLORO-ETHYL)-DIETHYL-AMINE(100-35-6)
• EPA Substance Registry System: (2-CHLORO-ETHYL)-DIETHYL-AMINE(100-35-6)

Safety Data

• Hazardous Substances Data: 100-35-6(Hazardous Substances Data)

Usage

Carcinogenicity

No studies to assess carcinogenic potential were found. In addition, this chemical has not been evaluated for carcinogenicity potential by the IARC or ACGIH. However, its dimethyl analog produced lung tumors in strain A mice following intraperitoneal injection.

InChI:InChI=1/C6H14ClN.H2O4S/c1-3-8(4-2)6-5-7;1-5(2,3)4/h3-6H2,1-2H3;(H2,1,2,3,4)

Upstream product

• 14426-20-1 N,N-diethylethanolammonium chloride 
• 2210-36-8 diethylaziridinium chloride 
• 869-24-9 2-chloro-N,N-diethylethylamine hydrochloride 
• 100-37-8 2-(Diethylamino)ethanol 

Downstream Products

• 72395-46-1 1-(2-diethylamino-ethyl)-indole 
• 26628-88-6 N,N-diethyl-2-methyltryptamine 
• 314-35-2 7-[2-(diethylamino)ethyl]theophylline 
• 93990-18-2 1-[2-(2-diethylamino-ethoxy)-phenyl]-2,5-dimethyl-pyrrole 
• 93999-62-3 4-(4-diethylamino-2-phenyl-butyryl)-morpholine 
• 24539-72-8 N,N-diethylaminoethyl xanthene-9-carboxylate 
• 53230-07-2 cyclopent-2-enyl-[2]thienyl-acetic acid-(2-diethylamino-ethyl ester) 
• 100575-54-0 {2-[2-(4-chloro-benzyl)-benzoimidazol-1-yl]-ethyl}-diethyl-amine 
• 100-36-7 N,N-diethylethylenediamine 
• 116535-42-3 5-(2-diethylamino-ethylamino)-8-methyl-2-phenyl-thiochromen-4-one 
• 97829-68-0 1-[2-(2-diethylamino-ethoxy)-phenyl]-2,5-diphenyl-pyrrole 
• 34341-24-7 3-(2-diethylamino-ethyl)-5,5-diphenyl-imidazolidine-2,4-dione 
• 102571-35-7 [2-(4-acetylamino-phenylsulfanyl)-ethyl]-diethyl-methyl-ammonium; iodide 

Relevant articles and documents

Understanding the Alkylation Mechanism of 3-Chloropiperidines – NMR Kinetic Studies and Isolation of Bicyclic Aziridinium Ions

The present study describes the kinetic analysis of the 3-chloropiperidine alkylation mechanism. These nitrogen mustard-based compounds are expected to react via a highly electrophilic bicyclic aziridinium ion, which is readily attacked by nucleophiles. Halide abstraction using silver salts with weakly coordinating anions lead to the isolation of these proposed intermediates, whereas their structure was confirmed by single crystal XRD. Kinetic studies of the aziridinium ions also revealed notable reactivity differences of the C5 gem-methylated compounds and their unmethylated counterparts. The observed reactivity trends were also reflected by NMR studies in aqueous solution and DNA alkylation experiments of the related 3-chloropiperidines. Therefore, the underlying Thorpe-Ingold effect might be considered as another option to adjust the alkylation activity of these compounds.

Isoflavone amide type derivative, preparation method and medical application thereof

The invention relates to the field of medicinal chemistry, and relates to an isoflavone amide type derivative, a preparation method and a medical application thereof, in particular to an isoflavone amide type derivative with the general formula (I), a preparation method thereof, medicine compositions including the isoflavone amide type derivative and a medical application thereof, especially an application of the isoflavone amide type derivative as a medicine for preventing or curing hyperlipemia, obesity or type II diabetes. The general formula (I) is shown in the description.

KINETIC STUDIES OF THE REACTIONS OF 2-DIETHYLAMINOETHYLCHLORIDE WITH NUCLEOPHILIC REAGENTS IN N,N-DIMETHYLFORMAMIDE

The kinetics of the reactions of 2-diethylaminoethylchloride with nucleophilic reagents have been studied in N,N-dimethylformamide from 33 to 80 deg C.An ethyleneimmonium ion is easily formed from 2-diethylaminoethylchloride by the participation of the ne