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Vardenafil hydrochloride trihydrate

Base Information Edit
  • Chemical Name:Vardenafil hydrochloride trihydrate
  • CAS No.:224785-90-4
  • Molecular Formula:C23H32N6O4S
  • Molecular Weight:488.611
  • Hs Code.:
  • Mol file:224785-90-4.mol
Vardenafil hydrochloride trihydrate

Synonyms:Piperazine,1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-(9CI);2-[2-Ethoxy-5-(4-ethylpiperazin-1-yl-1-sulfonyl)phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one;Nuviva;BAY 38-9456;1-((3-(3,4-Dihydro-5-methyl-4-oxo-7-propylimidazo(5,1-f)-as-triazin-2-yl)-4-ethoxyphenyl)sulfonyl)-4-ethylpiperazine;Vivanza;

Suppliers and Price of Vardenafil hydrochloride trihydrate
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Sigma-Aldrich
  • Vardenafil hydrochloride trihydrate European Pharmacopoeia (EP) Reference Standard
  • $ 190.00
  • Sigma-Aldrich
  • Zopiclone-D4 solution 100?μg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?
  • 1 mL
  • $ 145.00
  • Sigma-Aldrich
  • Vardenafil dihydrochloride solution 1.0?mg/mLinmethanol(asfreebase),ampuleof1?mL,certifiedreferencemateri
  • 1 mL
  • $ 134.00
  • Sigma-Aldrich
  • Vardenafil dihydrochloride solution
  • 902-1ml
  • $ 130.00
  • Medical Isotopes, Inc.
  • VardenafilDiHCl
  • 50 mg
  • $ 1880.00
  • Medical Isotopes, Inc.
  • Vardenafil-d5HCl
  • 1 mg
  • $ 675.00
  • Matrix Scientific
  • Vardenafil
  • 1g
  • $ 472.00
  • American Custom Chemicals Corporation
  • VARDENAFIL 95.00%
  • 10MG
  • $ 255.15
  • American Custom Chemicals Corporation
  • VARDENAFIL 95.00%
  • 1G
  • $ 722.80
  • AK Scientific
  • Vardenafil
  • 10mg
  • $ 98.00
Total 150 raw suppliers
Chemical Property of Vardenafil hydrochloride trihydrate Edit
Chemical Property:
  • Appearance/Colour:White crystalline powder 
  • Vapor Pressure:5.17E-19mmHg at 25°C 
  • Melting Point:230-235 °C 
  • Boiling Point:692.2 °C at 760 mmHg 
  • PKA:9.86±0.20(Predicted) 
  • Flash Point:372.5 °C 
  • PSA:121.28000 
  • Density:1.37 g/cm3 
  • LogP:4.63100 
  • Storage Temp.:?20°C 
  • Water Solubility.:7mg/L at 20℃ 
Purity/Quality:

98%min , *data from raw suppliers

Vardenafil hydrochloride trihydrate European Pharmacopoeia (EP) Reference Standard *data from reagent suppliers

Safty Information:
  • Pictogram(s): F,Xn 
  • Hazard Codes:F,Xn 
  • Statements: 11-20/21/22-36 
  • Safety Statements: 16-36/37 
MSDS Files:

SDS file from LookChem

Useful:
  • Description Vardenafil is a new PDE5 inhibitor launched for oral treatment of male erectile dysfunction and it has significant structural similarity with sildenafil (Viagra?), which was the first PDE5 inhibitor introduced in 1998 for this indication. Vardenafil is synthesized in three steps starting with a cyclization reaction of 2-ethyoxybenzamidine with 2-butyramidopropionic acid and ethoxyallyl chloride to construct the imidazotriazine ring system, followed by sulfonation to the corresponding sulfonyl chloride and subsequent condensation with 1-ethylpiperazine. The potency of PDE5 inhibition by vardenafil (IC50=0.7 nM) is ~10 times greater than that of sildenafil (IC50=6.6 nM). Vardenafil is typically administered in single doses of 10 and 20 mg. The time to reach maximum plasma concentration is 0.75 h, which is slightly shorter than those of sildenafil (tmax=1.16 h) and tadalafil (tmax=2h), and the half-life is 4–5 h. Although it is almost completely absorbed following oral administration, the mean absolute bioavailability of a 10 mg dose is ~15%, resulting from extensive first pass metabolism. Vardenafil is metabolized in the liver primarily by CYP3A4 and is eliminated mainly in feces. In clinical studies, 10–20 mg doses of vardenafil was well tolerated and efficacious in patients with ED of various severities, including subjects with comorbidities such as diabetes mellitus or hypertension or hyperlipidemia. The side-effect profile of vardenafil is similar to that of sildenafil, with headache, flushing, dyspepsia and nasal congestion being the most common adverse events. Vardenafil has systemic vasodilatory properties, which can cause transient decrease in supine blood pressure; however, it does not appear to translate into clinical effects. The mean maximum decreases in supine systolic blood pressure following 20 and 40 mg vardenafil were 6.9 and 4.3 mmHg, respectively, when compared to placebo. However, single and multiple oral doses of vardenafil up to 40 mg produced no clinically relevant changes in the ECGs of normal male volunteers.
  • Uses erectil dysfunction;PDE5 inhibitor Vardenafil Hydrochloride Trihydrate (cas# 330808-88-3) has therapeutic applications and used in cosmetics and personal care products.
  • Clinical Use Treatment of erectile dysfunction
  • Drug interactions Potentially hazardous interactions with other drugs Alpha-blockers: enhanced hypotensive effect - avoid for 6 hours after alpha-blockers (max dose 5 mg). Antifungals: concentration increased by ketoconazole, and itraconazole - avoid concomitant use. Antivirals: concentration increased by fosamprenavir, indinavir and ritonavir- avoid with indinavir and ritonavir; increased risk of ventricular arrhythmias with saquinavir - avoid; avoid with telaprevir, use tipranavir with caution. Cobicistat: concentration of vardenafil possibly increased - reduce dose of vardenafil. Grapefruit juice: concentration possibly increased - avoid concomitant use. Nicorandil: possibly enhanced hypotensive effect - avoid concomitant use. Nitrates: possibly enhanced hypotensive effect - avoid concomitant use. Riociguat: enhanced hypotensive effect - avoid concomitant use.
Technology Process of Vardenafil hydrochloride trihydrate

There total 21 articles about Vardenafil hydrochloride trihydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With sodium hydroxide; In water; pH=9 - 10;
Guidance literature:
N-[1-[3-[2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-phenyl]-2,5-dihydro-5-oxo-1,2,4-triazin-6-yl]ethyl]-butanamide; With trichlorophosphate; at 80 ℃; for 2h;
With sodium carbonate; In water; pH=8; Product distribution / selectivity;
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