2-{2-ethoxy-5-[(4-ethyl-4-hydroxy-4λ5-piperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propyl imidazo-[5,1-f]-1,2,4-triazin-4(3H)-one N-oxide

Base Information

Chemical Name:2-{2-ethoxy-5-[(4-ethyl-4-hydroxy-4λ5-piperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propyl imidazo-[5,1-f]-1,2,4-triazin-4(3H)-one N-oxide
CAS No.:448184-48-3
Molecular Formula:C₂₃H₃₂N₆O₅S
Molecular Weight:504.61
Hs Code.:

Synonyms:2-{2-ethoxy-5-[(4-ethyl-4-hydroxy-4λ5-piperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propyl imidazo-[5,1-f]-1,2,4-triazin-4(3H)-one N-oxide

Suppliers and Price of 2-{2-ethoxy-5-[(4-ethyl-4-hydroxy-4λ5-piperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propyl imidazo-[5,1-f]-1,2,4-triazin-4(3H)-one N-oxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
VardenafilN-Oxide
50mg
$ 400.00

Total 10 raw suppliers

Chemical Property of 2-{2-ethoxy-5-[(4-ethyl-4-hydroxy-4λ5-piperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propyl imidazo-[5,1-f]-1,2,4-triazin-4(3H)-one N-oxide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

VardenafilN-Oxide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Vardenafil N-Oxide is an impurity compound of Vardenafil Hydrochloride. It is used in the treatment of erectile dysfunction. It also functions an inhibitor of phosphodiestrase type 5(PDE-5) enzyme.

Technology Process of 2-{2-ethoxy-5-[(4-ethyl-4-hydroxy-4λ5-piperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propyl imidazo-[5,1-f]-1,2,4-triazin-4(3H)-one N-oxide

There total 3 articles about 2-{2-ethoxy-5-[(4-ethyl-4-hydroxy-4λ5-piperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propyl imidazo-[5,1-f]-1,2,4-triazin-4(3H)-one N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 224785-90-4
vardenafil

: 448184-48-3
2-{2-ethoxy-5-[(4-ethyl-4-hydroxy-4λ5-piperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propyl imidazo-[5,1-f]-1,2,4-triazin-4(3H)-one N-oxide

Guidance literature:: With peracetic acid; In dichloromethane; at 0 - 5 ℃; for 2h;
DOI:10.1080/00397911.2011.585268

Reference yield:

: 224789-21-3
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

: 448184-48-3
2-{2-ethoxy-5-[(4-ethyl-4-hydroxy-4λ5-piperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propyl imidazo-[5,1-f]-1,2,4-triazin-4(3H)-one N-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: chlorosulfonic acid / 0 - 5 °C

2: dichloromethane / 25 - 30 °C

3: peracetic acid / dichloromethane / 2 h / 0 - 5 °C

With peracetic acid; chlorosulfonic acid; In dichloromethane;
DOI:10.1080/00397911.2011.585268

Reference yield:

: 224789-26-8
4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)-benzenelsulfonic acid chloride

: 448184-48-3
2-{2-ethoxy-5-[(4-ethyl-4-hydroxy-4λ5-piperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propyl imidazo-[5,1-f]-1,2,4-triazin-4(3H)-one N-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 25 - 30 °C

2: peracetic acid / dichloromethane / 2 h / 0 - 5 °C

With peracetic acid; In dichloromethane;
DOI:10.1080/00397911.2011.585268