1-METHYL-5-NITROINDOLINE

Base Information

• Chemical Name: 1-METHYL-5-NITROINDOLINE
• CAS No.: 18711-25-6
• Molecular Formula: C9H10N2O2
• Molecular Weight: 178.19
• Hs Code.: 2933990090
• Mol file: 18711-25-6.mol

Synonyms:Indoline,1-methyl-5-nitro- (8CI);1-Methyl-5-nitroindoline;N-Methyl-5-nitroindoline;

Chemical Property of 1-METHYL-5-NITROINDOLINE

Chemical Property:

• Vapor Pressure: 0.000126mmHg at 25°C
• Refractive Index: 1.603
• Boiling Point: 334.7 °C at 760 mmHg
• Flash Point: 156.2 °C
• PSA: 49.06000
• Density: 1.259 g/cm³
• LogP: 2.17530
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-Methyl-5-nitroindoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-METHYL-5-NITROINDOLINE

There total 2 articles about 1-METHYL-5-NITROINDOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5-nitro-2,3-dihydro-1H-indole (32692-19-6) + methyl iodide (74-88-4) → 1-Methyl-5-nitroindoline (18711-25-6)

Guidance literature:

With potassium hydroxide; In acetone; at 0 - 20 ℃;

Reference yield:

→ 1-Methyl-5-nitroindoline (18711-25-6)

Guidance literature:

Thermolyse d.Hydrazons 6 (R¹ = Dimethylamino, R² = NO2, R³ = H);

DOI:10.1039/j39710003693

Reference yield: 75.0%

1-Methyl-5-nitroindoline (18711-25-6) → 1-methyl-5-nitro-1H-indole (29906-67-0)

Guidance literature:

With N-hydroxyphthalimide; copper(II) acetate monohydrate; In acetonitrile; at 120 ℃; for 16h; Reagent/catalyst; Sealed tube;

DOI:10.1002/adsc.202000767

upstream raw materials:

5-nitro-2,3-dihydro-1H-indole

methyl iodide

Downstream raw materials:

1-methylindolin-5-amine

1-methyl-5-nitro-1H-indole