Pyrimido[1,2-a]purin-10(1H)-one

Base Information

Chemical Name:Pyrimido[1,2-a]purin-10(1H)-one
CAS No.:103408-45-3
Molecular Formula:C₈H₅N₅O
Molecular Weight:187.161
Hs Code.:
DSSTox Substance ID:DTXSID60145820
Nikkaji Number:J427.481D
Wikipedia:M1G
Wikidata:Q4043340
Mol file:103408-45-3.mol

Synonyms:guanine-malondialdehyde adduct;pyrimido(1,2-a)purin-10(1H)-one

Suppliers and Price of Pyrimido[1,2-a]purin-10(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Pyrimido[1,2-a]purin-10(1H)-one
250mg
$ 1355.00

AccelPharmtech
Pyrimido[1,2-a]purin-10(3H)-one 97.00%
5G
$ 1700.00

AccelPharmtech
Pyrimido[1,2-a]purin-10(3H)-one 97.00%
1G
$ 1530.00

Total 2 raw suppliers

Chemical Property of Pyrimido[1,2-a]purin-10(1H)-one

Chemical Property:

Vapor Pressure:1.23E-12mmHg at 25°C
Melting Point:>179°C (Dec.)
Boiling Point:561.5°Cat760mmHg
PKA:11.23±0.20(Predicted)
Flash Point:293.4°C
PSA：75.94000
Density:1.82g/cm³
LogP:-0.03420
Storage Temp.:-20°C Freezer
Solubility.:Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
XLogP3:-0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:187.04940980
Heavy Atom Count:14
Complexity:372

Purity/Quality:

96% ^*data from raw suppliers

Pyrimido[1,2-a]purin-10(1H)-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CN2C(=O)C3=C(N=CN3)N=C2N=C1
Uses Labelled M1G. M1G is a secondary DNA damage product arising from primary reactive oxygen species (ROS) damage to membrane lipids or deoxyribose. ldehyde with DNA. M1G is a secondary DNA damage product arising from primary reactive oxygen species (ROS) damage to membrane lipids or deoxyribose. NA. M1G is a secondary DNA damage product arising from primary reactive oxygen species (ROS) damage to membrane lipids or deoxyribose. It is a guanine adduct formed by reaction of malondialdehyde with DNA.

Technology Process of Pyrimido[1,2-a]purin-10(1H)-one

There total 5 articles about Pyrimido[1,2-a]purin-10(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122-31-6
malondialdehyde bis(diethyl acetal)

: 635-39-2
Guanine hydrochloride

: 103408-45-3
pyrimido[1,2-a]purin-10(3H)-one

Guidance literature:: With hydrogenchloride; In methanol; at 70 ℃; for 0.5h;
DOI:10.1021/tx990141i

Reference yield:

: 542-78-9
Malondialdehyde

: 73-40-5
2-amino-1,9-dihydro-6H-purin-6-one

: 103408-45-3
pyrimido[1,2-a]purin-10(3H)-one

: C₁₁H₉N₅O₃

Guidance literature:: With phosphate buffer; In water; at 37 ℃; for 24h; Product distribution; study of the reaction of MDA with guanine and guanine nucleosides, formation of adducts containing pyrimido- and oxadiazabicyclononene residues in the base-pairing region;
DOI:10.1021/ja00266a065

Reference yield:

: 73-40-5
2-amino-1,9-dihydro-6H-purin-6-one

: 86030-90-2
β-(p-nitrophenoxy)acrolein

: 103408-45-3
pyrimido[1,2-a]purin-10(3H)-one

: C₁₁H₉N₅O₃

Guidance literature:: With phosphate buffer; In water; at 37 ℃; for 24h; Product distribution; study of the reaction of various β-substituted acroleins with guanine and guanine nucleosides, formation of adducts containing pyrimido- and oxadiazabicyclononene residues in the base-pairing region;
DOI:10.1021/ja00266a065