2(1H)-Pyridinone, 3-(4-chlorobenzoyl)-1,6-dimethyl-4-phenyl-

Base Information

• Chemical Name: 2(1H)-Pyridinone, 3-(4-chlorobenzoyl)-1,6-dimethyl-4-phenyl-
• CAS No.: 143572-56-9
• Molecular Formula: C₂₀H₁₆ClNO₂
• Molecular Weight: 337.806
• DSSTox Substance ID: DTXSID10162461
• Nikkaji Number: J492.417G
• Wikidata: Q83031136
• Mol file: 143572-56-9.mol

Synonyms:143572-56-9;BRN 5824113;2(1H)-Pyridinone, 3-(4-chlorobenzoyl)-1,6-dimethyl-4-phenyl-;3-(4-Chlorobenzoyl)-1,6-dimethyl-4-phenyl-2(1H)-pyridinone;3-(4-chlorobenzoyl)-1,6-dimethyl-4-phenylpyridin-2-one;C20H16ClNO2;C20-H16-Cl-N-O2;DTXSID10162461;ZYNYLFMTQMOINF-UHFFFAOYSA-N;LS-133027;3-(4-Chlorobenzoyl)-1,6-dimethyl-4-phenylpyridin-2(1H)-one

Chemical Property of 2(1H)-Pyridinone, 3-(4-chlorobenzoyl)-1,6-dimethyl-4-phenyl-

Chemical Property:

• Vapor Pressure: 7.09E-11mmHg at 25°C
• Boiling Point: 519°C at 760 mmHg
• Flash Point: 267.7°C
• PSA: 39.07000
• Density: 1.261g/cm³
• LogP: 4.24510
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 337.0869564
• Heavy Atom Count: 24
• Complexity: 578

Purity/Quality:

3-(4-CHLOROBENZOYL)-1,6-DIMETHYL-4-PHENYL-2(1H)-PYRIDINONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C(=O)N1C)C(=O)C2=CC=C(C=C2)Cl)C3=CC=CC=C3

Technology Process of 2(1H)-Pyridinone, 3-(4-chlorobenzoyl)-1,6-dimethyl-4-phenyl-

There total 4 articles about 2(1H)-Pyridinone, 3-(4-chlorobenzoyl)-1,6-dimethyl-4-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

3-(4-Chloro-benzoyl)-6-methyl-4-phenyl-1H-pyridin-2-one (143572-48-9) + methyl iodide (74-88-4) → 3-(4-Chloro-benzoyl)-1,6-dimethyl-4-phenyl-1H-pyridin-2-one (143572-56-9)

Guidance literature:

With potassium hydroxide; In ethanol; for 3h; Heating;

DOI:10.1007/BF00772938

Reference yield:

6-methyl-2-methoxy-4-phenylnicotinonitrile (60847-61-2) → 3-(4-Chloro-benzoyl)-1,6-dimethyl-4-phenyl-1H-pyridin-2-one (143572-56-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 40 percent / diethyl ether / 8 h / Heating

2: 58 percent / aq. HCl / ethanol / 1 h / Heating

3: 42 percent / aq. KOH / ethanol / 3 h / Heating

With hydrogenchloride; potassium hydroxide; In diethyl ether; ethanol;

DOI:10.1007/BF00772938

Reference yield:

(4-chlorphenyl)magnesium bromide (873-77-8) → 3-(4-Chloro-benzoyl)-1,6-dimethyl-4-phenyl-1H-pyridin-2-one (143572-56-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 40 percent / diethyl ether / 8 h / Heating

2: 58 percent / aq. HCl / ethanol / 1 h / Heating

3: 42 percent / aq. KOH / ethanol / 3 h / Heating

With hydrogenchloride; potassium hydroxide; In diethyl ether; ethanol;

DOI:10.1007/BF00772938

upstream raw materials:

3-(4-Chloro-benzoyl)-6-methyl-4-phenyl-1H-pyridin-2-one

methyl iodide

6-methyl-2-methoxy-4-phenylnicotinonitrile

(4-chlorphenyl)magnesium bromide