17-(iodoethynyl)estra-1,3,5(10)-triene-3,17-diol

Base Information

Chemical Name:17-(iodoethynyl)estra-1,3,5(10)-triene-3,17-diol
CAS No.:70761-64-7
Molecular Formula:C20H23IO2
Molecular Weight:422.2999
Hs Code.:

Synonyms:17-(iodoethynyl)estra-1,3,5(10)-triene-3,17-diol;I-EE2;(17alpha)-21-Iodo-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol;17alpha-Iodoethynylestradiol;

Suppliers and Price of 17-(iodoethynyl)estra-1,3,5(10)-triene-3,17-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 17-(iodoethynyl)estra-1,3,5(10)-triene-3,17-diol

Chemical Property:

Vapor Pressure:5.21E-12mmHg at 25°C
Boiling Point:528.8°Cat760mmHg
PKA:10.23±0.60(Predicted)
Flash Point:273.6°C
PSA：40.46000
Density:1.6g/cm³
LogP:4.37530

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 17-(iodoethynyl)estra-1,3,5(10)-triene-3,17-diol

There total 3 articles about 17-(iodoethynyl)estra-1,3,5(10)-triene-3,17-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 57-63-6
ethinyl estradiol

: 70761-64-7
17α-(iodoethynyl)estradiol

Guidance literature:: With pyridine; copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; iodine; In tetrahydrofuran; for 52h;
DOI:10.1016/0039-128X(91)90070-C

Reference yield:

: C₃₀H₃₉IO₄

: 70761-64-7
17α-(iodoethynyl)estradiol

Guidance literature:: With water; toluene-4-sulfonic acid; In ethanol; at 60 ℃; for 4h; Yield given;
DOI:10.1016/0039-128X(91)90070-C

Reference yield:

: 3589-92-2
17α-ethynylestra-3,17β-diol 3,17-bis(tetrahydropyranyl ether)

: 70761-64-7
17α-(iodoethynyl)estradiol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) methyllithium, 2.) iodine / 1.) hexane, THF, RT, 1.5 h, 2.) hexane, THF, 8 h

2: p-toluenesulfonic acid monohydrate, water / aq. ethanol / 4 h / 60 °C

With water; methyllithium; iodine; toluene-4-sulfonic acid; In ethanol;
DOI:10.1016/0039-128X(91)90070-C