Butanediamide,N1-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-N4-hydroxy-2-(2-methylpropyl)-,(2R)-

Base Information

• Chemical Name: Butanediamide,N1-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-N4-hydroxy-2-(2-methylpropyl)-,(2R)-
• CAS No.: 145337-55-9
• Molecular Formula: C₁₅H₂₉N₃O₄
• Molecular Weight: 315.413
• Mol file: 145337-55-9.mol

Synonyms:Butanediamide,N1-[2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-N4-hydroxy-2-(2-methylpropyl)-,[S-(R*,S*)]-; GI 4747; Ro 31-9790

Chemical Property of Butanediamide,N1-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-N4-hydroxy-2-(2-methylpropyl)-,(2R)-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Butanediamide,N1-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-N4-hydroxy-2-(2-methylpropyl)-,(2R)-

There total 24 articles about Butanediamide,N1-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-N4-hydroxy-2-(2-methylpropyl)-,(2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(S)-N4-(benzyloxy)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-2-isobutylsuccinamide (927828-06-6) → (S)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-N4-hydroxy-2-isobutylsuccinamide (927827-97-2,145337-55-9)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃;

Reference yield: 82.0%

(R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-5-methyl-hexanoic acid (145337-57-1) → (2R)-N1-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-N4-hydroxy-2-(2-methylpropyl)-butanediamide (145337-55-9)

Guidance literature:

With dmap; 4-(aminoxymethyl)-2-methoxyphenoxymethyl-copoly(styrene-1..; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 18h;

(R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-5-methyl-hexanoic acid; With trifluoroacetic acid; In dichloromethane; for 0.25h;

DOI:10.1016/S0040-4020(99)00347-6

Reference yield: 78.0%

N4-(2,4-dimethoxy-benzyloxy)-N1-(2,2-dimethyl-1-methylcarbamoyl-propyl)-2-isobutyl-succinamide → (2R)-N1-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-N4-hydroxy-2-(2-methylpropyl)-butanediamide (145337-55-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 0.25h;

DOI:10.1016/S0040-4039(98)01760-2

upstream raw materials:

(R)-N⁴-Benzyloxy-N¹-((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-2-isobutyl-succinamide

(R)-methyl 3-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-ylcarbamoyl)-5-methylhexanoate

(R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-5-methyl-hexanoic acid

(S)-2-amino-N,3,3-trimethylbutanamide