2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-ethylacetamide

Base Information

Chemical Name:2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-ethylacetamide
CAS No.:74169-70-3
Molecular Formula:C₁₂H₁₂N₂O₃
Molecular Weight:232.239
Hs Code.:

Synonyms:N,N-phthaloyl-glycine ethylamide;Phthalimidoacetic acid ethylamide;2-ISOINDOLINEACETAMIDE,1,3-DIOXO-N-ETHYL;N,N-Phthaloyl-glycin-aethylamid;N,N-phthaloyl-glycin-ethylamide;1,3-Dioxo-N-ethyl-2-isoindolineacetamide;

Suppliers and Price of 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-ethylacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-(1,3-DIOXOISOINDOL-2-YL)-N-ETHYLACETAMIDE 95.00%
5MG
$ 505.97

Total 0 raw suppliers

Chemical Property of 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-ethylacetamide

Chemical Property:

Vapor Pressure:2.04E-08mmHg at 25°C
Boiling Point:453.6°Cat760mmHg
Flash Point:228.1°C
PSA：69.97000
Density:1.296g/cm³
LogP:1.19690

Purity/Quality:: 2-(1,3-DIOXOISOINDOL-2-YL)-N-ETHYLACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-ethylacetamide

There total 3 articles about 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-ethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 6780-38-7
N-phthaloylglycine chloride

: 75-04-7,85404-22-4
ethylamine

: 74169-70-3
2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-N-ethyl-acetamide

Guidance literature:: In acetonitrile; for 1h; Ambient temperature;
DOI:10.1007/BF00765906

Reference yield:

: 4702-13-0
N-phthaloylglycine

: 74169-70-3
2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-N-ethyl-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / 1 h / Heating

2: 58 percent / CH₂Cl₂ / 2 h / 20 °C

With thionyl chloride; In dichloromethane;
DOI:10.1002/1521-4184(200110)334:10<323::AID-ARDP323>3.0.CO;2-O

Reference yield:

: 85-44-9
phthalic anhydride

: 74169-70-3
2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-N-ethyl-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / Et₃N / toluene / 2 h / Heating

2: SOCl₂ / 1 h / Heating

3: 58 percent / CH₂Cl₂ / 2 h / 20 °C

With thionyl chloride; triethylamine; In dichloromethane; toluene;
DOI:10.1002/1521-4184(200110)334:10<323::AID-ARDP323>3.0.CO;2-O