(2E)-N-methyl-3-phenyl-N-[(E)-2-phenylethenyl]prop-2-enamide

Base Information

Chemical Name:(2E)-N-methyl-3-phenyl-N-[(E)-2-phenylethenyl]prop-2-enamide
CAS No.:77527-97-0
Molecular Formula:C₁₈H₁₇NO
Molecular Weight:263.339
Hs Code.:
DSSTox Substance ID:DTXSID401183255
Nikkaji Number:J1.315.527E
Wikidata:Q76416844
Metabolomics Workbench ID:48249

Synonyms:(E)-N-methyl-3-phenyl-N-[(E)-2-phenylethenyl]prop-2-enamide;(2E)-N-methyl-3-phenyl-N-[(E)-2-phenylethenyl]prop-2-enamide;121817-37-6;Lansamide I;N-Methyl-N-cis-styrylcinnamamide;DTXSID401183255;(2E)-N-Methyl-3-phenyl-N-[(1E)-2-phenylethenyl]-2-propenamide

Suppliers and Price of (2E)-N-methyl-3-phenyl-N-[(E)-2-phenylethenyl]prop-2-enamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (2E)-N-methyl-3-phenyl-N-[(E)-2-phenylethenyl]prop-2-enamide

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:4
Exact Mass:263.131014166
Heavy Atom Count:20
Complexity:346

Purity/Quality:: 95%+ or 98%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C=CC1=CC=CC=C1)C(=O)C=CC2=CC=CC=C2
Isomeric SMILES:CN(/C=C/C1=CC=CC=C1)C(=O)/C=C/C2=CC=CC=C2

Technology Process of (2E)-N-methyl-3-phenyl-N-[(E)-2-phenylethenyl]prop-2-enamide

There total 10 articles about (2E)-N-methyl-3-phenyl-N-[(E)-2-phenylethenyl]prop-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 121817-36-5
(2E)-3-phenyl-N-[(E)-2-phenylvinyl]acrylamide

: 74-88-4
methyl iodide

: 77527-97-0
(2E)-N-methyl-3-phenyl-N-[(E)-2-phenylvinyl]acrylamide

Guidance literature:: DOI:10.1016/S0040-4039(00)00477-9

Reference yield:

: 621-79-4,22031-64-7
cinnamamide

: 77527-97-0
(2E)-N-methyl-3-phenyl-N-[(E)-2-phenylvinyl]acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1: 58 percent / DIBAL / hexane; tetrahydrofuran / 0 °C

2: 67 percent / CH₂Cl₂; tetrahydrofuran / 20 °C

3: 64 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 0.5 h / -10 - 0 °C

4: DBU / tetrahydrofuran / 23 °C

5: 88 percent / NaH / tetrahydrofuran / 23 °C

With sodium hydride; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.tet.2004.05.082

Reference yield:

: 122-78-1
phenylacetaldehyde

: 77527-97-0
(2E)-N-methyl-3-phenyl-N-[(E)-2-phenylvinyl]acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1: 58 percent / DIBAL / hexane; tetrahydrofuran / 0 °C

2: 67 percent / CH₂Cl₂; tetrahydrofuran / 20 °C

3: 64 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 0.5 h / -10 - 0 °C

4: DBU / tetrahydrofuran / 23 °C

5: 88 percent / NaH / tetrahydrofuran / 23 °C

With sodium hydride; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.tet.2004.05.082