Dispiro[2H-quinolizine-3(4H),2'(3'H)-thiophene- 4'(5'H),3''(4''H)-[2H]quinolizine],6,6''-di-3- furanyldodecahydro-9,9''-dimethyl-,stereoisomer

Base Information

Chemical Name:Dispiro[2H-quinolizine-3(4H),2'(3'H)-thiophene- 4'(5'H),3''(4''H)-[2H]quinolizine],6,6''-di-3- furanyldodecahydro-9,9''-dimethyl-,stereoisomer
CAS No.:67314-63-0
Molecular Formula:
Molecular Weight:
Hs Code.:

Synonyms:

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Chemical Property of Dispiro[2H-quinolizine-3(4H),2'(3'H)-thiophene- 4'(5'H),3''(4''H)-[2H]quinolizine],6,6''-di-3- furanyldodecahydro-9,9''-dimethyl-,stereoisomer

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of Dispiro[2H-quinolizine-3(4H),2'(3'H)-thiophene- 4'(5'H),3''(4''H)-[2H]quinolizine],6,6''-di-3- furanyldodecahydro-9,9''-dimethyl-,stereoisomer

There total 12 articles about Dispiro[2H-quinolizine-3(4H),2'(3'H)-thiophene- 4'(5'H),3''(4''H)-[2H]quinolizine],6,6''-di-3- furanyldodecahydro-9,9''-dimethyl-,stereoisomer which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.8%

: 1418134-80-1
C₁₅H₂₀NO⁽¹⁺⁾*C₂F₃O₂^(1-)

: 67314-63-0
(-)-neothiobinupharidine

: 30343-74-9
thionuphlutine B

: 30343-72-7
thiobinupharidine

: 4850-09-3
(-)-neothiobinupharidine

Guidance literature:: C₁₅H₂₀NO⁽¹⁺⁾*C₂F₃O₂^(1-); With disodium tetrasulfide; In dimethyl sulfoxide; for 6h; Inert atmosphere;

With sodium tetrahydroborate; In methanol; for 0.5h; Solvent; Concentration; Inert atmosphere;
DOI:10.1021/ja310778t

Reference yield:

: 862672-54-6
(5R,6S)-6-allyl-5-methylpiperidin-2-one

: 67314-63-0
(-)-neothiobinupharidine

: 30343-74-9
thionuphlutine B

: 30343-72-7
thiobinupharidine

: 4850-09-3
(-)-neothiobinupharidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium diisopropyl amide; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: 0 - 22 °C

2.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / benzene / Inert atmosphere; Reflux

2.2: 22 °C / Inert atmosphere

3.1: n-butyllithium / diethyl ether; hexane / 0.33 h / -78 °C / Inert atmosphere

3.2: 1.5 h / -78 - 22 °C / Inert atmosphere

3.3: Inert atmosphere

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C / Inert atmosphere

5.1: dichloromethane / 2 h / 0 °C / Inert atmosphere

6.1: disodium tetrasulfide / dimethyl sulfoxide / 6 h / Inert atmosphere

6.2: 0.5 h / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; N,N,N,N,N,N-hexamethylphosphoric triamide; disodium tetrasulfide; n-butyllithium; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; benzene;
DOI:10.1021/ja310778t

Reference yield:

: 1418134-72-1
C₁₆H₂₉NOSi

: 67314-63-0
(-)-neothiobinupharidine

: 30343-74-9
thionuphlutine B

: 30343-72-7
thiobinupharidine

: 4850-09-3
(-)-neothiobinupharidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / benzene / Inert atmosphere; Reflux

1.2: 22 °C / Inert atmosphere

2.1: n-butyllithium / diethyl ether; hexane / 0.33 h / -78 °C / Inert atmosphere

2.2: 1.5 h / -78 - 22 °C / Inert atmosphere

2.3: Inert atmosphere

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C / Inert atmosphere

4.1: dichloromethane / 2 h / 0 °C / Inert atmosphere

5.1: disodium tetrasulfide / dimethyl sulfoxide / 6 h / Inert atmosphere

5.2: 0.5 h / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; disodium tetrasulfide; n-butyllithium; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; benzene;
DOI:10.1021/ja310778t