(13S)-Neothiobinupharidine

Base Information

• Chemical Name: (13S)-Neothiobinupharidine
• CAS No.: 30343-74-9
• Molecular Formula: C₃₀H₄₂N₂O₂S
• Molecular Weight: 494.742
• Mol file: 30343-74-9.mol

Synonyms:Neothiobinupharidine,(13S)-; Thionuphlutine B (8CI)

Chemical Property of (13S)-Neothiobinupharidine

Chemical Property:

• PSA: 58.06000
• LogP: 7.18150

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (13S)-Neothiobinupharidine

There total 35 articles about (13S)-Neothiobinupharidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

C31H44N2O4S → thionuphlutine B (30343-74-9) + (-)-6-hydroxythionuphlutine (183072-79-9)

Guidance literature:

With diisobutylaluminium hydride; In hexane; dichloromethane; at -89 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/jacs.7b07685

Reference yield: 23.8%

C15H20NO(1+)*C2F3O2(1-) (1418134-80-1) → (-)-neothiobinupharidine (67314-63-0) + thionuphlutine B (30343-74-9) + thiobinupharidine (30343-72-7) + (-)-neothiobinupharidine (4850-09-3)

Guidance literature:

C₁₅H₂₀NO⁽¹⁺⁾*C₂F₃O₂^(1-); With disodium tetrasulfide; In dimethyl sulfoxide; for 6h; Inert atmosphere;

With sodium tetrahydroborate; In methanol; for 0.5h; Solvent; Concentration; Inert atmosphere;

DOI:10.1021/ja310778t

Reference yield:

6'-hydroxythionuphlutine B → thionuphlutine B (30343-74-9)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 0.5h; Ambient temperature;

DOI:10.3987/COM-97-7878

upstream raw materials:

(R)-3-methyl-dihydro-furan-2-one

(-)-(3R)-methyl-4-penten-1-ol

Refernces

• 1、 Jansen, Daniel J.,Shenvi, Ryan A.. "Synthesis of (-)-neothiobinupharidine". supporting information. p. 1209 - 1212. Retrieved 2013/03/28.