5-METHYL-1-HEPTANOL

Base Information

• Chemical Name: 5-METHYL-1-HEPTANOL
• CAS No.: 7212-53-5
• Molecular Formula: C8H18 O
• Molecular Weight: 130.23
• Mol file: 7212-53-5.mol

Synonyms:(?à)-5-Methyl-1-heptanol;5-Ethylhexanol; 5-Methyl-1-heptanol

Chemical Property of 5-METHYL-1-HEPTANOL

Chemical Property:

• Vapor Pressure: 0.284mmHg at 25°C
• Refractive Index: 1.4272
• Boiling Point: 179.2°C at 760 mmHg
• PKA: 15.20±0.10(Predicted)
• Flash Point: 71.1°C
• PSA: 20.23000
• Density: 0.821g/cm³
• LogP: 2.19510

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Ethylhexanol can be used to treat hypertension.

Technology Process of 5-METHYL-1-HEPTANOL

There total 10 articles about 5-METHYL-1-HEPTANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl 5-methylheptanoate (89986-46-9) → 5-methyl-1-heptanol (7212-53-5)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether;

Reference yield: 90.0%

5-methyl-heptanoic acid ethyl ester (37492-11-8) → 5-methyl-1-heptanol (7212-53-5)

Guidance literature:

With lithium aluminium tetrahydride;

Reference yield:

1-bromo-2-methyl-butane (10422-35-2,99032-67-4,534-00-9,5973-11-5) → 5-methyl-1-heptanol (7212-53-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Mg / 1.) ether, 2.) ether, reflux, 16 h

2: 1.) NaBH₄, BF₃-etherate, 2.) 3 N aq. NaOH, 3.) 30percent aq. H₂O₂ / 1.) THF, 20-25 deg C, 20-25 min, 3.) THF, 30-35 deg C, 2 h

With sodium hydroxide; sodium tetrahydroborate; boron trifluoride diethyl etherate; dihydrogen peroxide; magnesium;

upstream raw materials:

methyl 5-methylheptanoate

5-methyl-heptanoic acid ethyl ester

5-methylhept-1-ene

oxirane

Downstream raw materials:

7-methyl-1-nonyne

(Z)-14-Methyl-8-Hexadecenal

(E)-14-Methyl-8-Hexadecenal

8-methyldecanoic acid methyl ester

Refernces

• 1、 Kulinkovich,Shevchuk,Isakov,Prokhorevich. "Reductive ethylation of homoallyl alcohols with a disubstituted double bond with ethylmagnesium bromide in the presence of titanium(IV) isopropoxide". . p. 659 - 664. Retrieved 2007/10/03.
• 2、 Zakharkin, L. I.,Petrushkina, E. A.. "SYNTHESIS OF (Z)- AND (E)-14-METHYL-8-HEXADECEN-1-OLS FROM METHYL (E)-5-METHYL-2,5-HEPTADIENOATE - THE CODIMER OF ISOPRENE AND METHYL ACRYLATE". . p. 37 - 41. Retrieved 2007/10/02.