5-[(2-chloroacetyl)amino]-2-hydroxy-benzoic acid

Base Information

• Chemical Name: 5-[(2-chloroacetyl)amino]-2-hydroxy-benzoic acid
• CAS No.: 80074-26-6
• Molecular Formula: C9H8 Cl N O4
• Molecular Weight: 229.62
• Hs Code.: 2924299090
• Mol file: 80074-26-6.mol

Synonyms:Benzoicacid, 5-[(chloroacetyl)amino]-2-hydroxy- (9CI); NSC 17829

Chemical Property of 5-[(2-chloroacetyl)amino]-2-hydroxy-benzoic acid

Chemical Property:

• Vapor Pressure: 4.03E-11mmHg at 25°C
• Boiling Point: 507.5°C at 760 mmHg
• Flash Point: 260.7°C
• PSA: 86.63000
• Density: 1.585g/cm³
• LogP: 1.34070

Purity/Quality:

99%min ^*data from raw suppliers

5-[(Chloroacetyl)amino]-2-hydroxybenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-[(2-chloroacetyl)amino]-2-hydroxy-benzoic acid

There total 4 articles about 5-[(2-chloroacetyl)amino]-2-hydroxy-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

5-Aminosalicylic Acid (89-57-6) + chloroacetyl chloride (79-04-9) → 5-[(chloroacetyl)amino]-2-hydroxybenzoic acid (80074-26-6)

Guidance literature:

With sodium acetate; acetic acid; In water; at 0 - 5 ℃;

DOI:10.1002/jhet.3474

Reference yield:

methyl 5-chloroacetamidosalicylate (80074-18-6) → 5-[(chloroacetyl)amino]-2-hydroxybenzoic acid (80074-26-6)

Guidance literature:

With sodium carbonate;

Reference yield:

methyl 5-amino-2-hydroxybenzoate (42753-75-3) → 5-[(chloroacetyl)amino]-2-hydroxybenzoic acid (80074-26-6)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene

2: natrium carbonate

With sodium carbonate; benzene;

upstream raw materials:

methyl 5-chloroacetamidosalicylate

5-Aminosalicylic Acid

chloroacetyl chloride

methyl 5-amino-2-hydroxybenzoate

Downstream raw materials:

5-[(N,N-diethyl-glycyl)-amino]-2-hydroxy-benzoic acid

5-[(N,N-diethyl-glycyl)-amino]-2-hydroxy-benzoic acid methyl ester

Refernces