p-Chlorophenylglyoxal N,N-dimethylhydrazone

Base Information

• Chemical Name: p-Chlorophenylglyoxal N,N-dimethylhydrazone
• CAS No.: 24346-19-8
• Molecular Formula: C10H11 Cl N2 O
• Molecular Weight: 210.6601
• Hs Code.: 2914700090
• Mol file: 24346-19-8.mol

Synonyms:p-Chlorophenylglyoxal N,N-dimethylhydrazone;4-Chlorophenylglyoxal N,N-dimethylhydrazone;BRN 2442532;GLYOXAL, p-CHLOROPHENYL-, DIMETHYL HYDRAZONE;24346-19-8;Glyoxal, (p-chlorophenyl)-, 2-(dimethylhydrazone);Benzeneacetaldehyde, 4-chloro-.alpha.-oxo-, aldehydo-(dimethylhydrazone);LS-72977

Chemical Property of p-Chlorophenylglyoxal N,N-dimethylhydrazone

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 313.8°Cat760mmHg
• Flash Point: 143.6°C
• PSA: 32.67000
• Density: 1.13g/cm³
• LogP: 2.07010
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 210.0559907
• Heavy Atom Count: 14
• Complexity: 220

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)N=CC(=O)C1=CC=C(C=C1)Cl
• Isomeric SMILES: CN(C)/N=C/C(=O)C1=CC=C(C=C1)Cl

Technology Process of p-Chlorophenylglyoxal N,N-dimethylhydrazone

There total 1 articles about p-Chlorophenylglyoxal N,N-dimethylhydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-(4-chloro-phenyl)-2,2-dihydroxy-ethanone (4996-21-8) + N,N-Dimethylhydrazine (57-14-7) → 4-chloro-α-oxo-benzeneacetaldehyde, aldehydo-(dimethylhydrazone) (24346-19-8)

Guidance literature:

In ethanol; for 24h; Ambient temperature;

DOI:10.1055/s-1991-26513

Reference yield: 55.0%

4-chloro-α-oxo-benzeneacetaldehyde, aldehydo-(dimethylhydrazone) (24346-19-8) → 1-(4-Chloro-phenyl)-2-(dimethyl-hydrazono)-ethanethione (136209-86-4)

Guidance literature:

With Lawessons reagent; In benzene; a.) 10 deg C, 5 min, b.) up to room temp., 10 min;

DOI:10.1055/s-1991-26513

Reference yield:

4-chloro-α-oxo-benzeneacetaldehyde, aldehydo-(dimethylhydrazone) (24346-19-8) → 6-(4-Chloro-phenyl)-2H-[1,4]thiazine-3-carbaldehyde (136209-85-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / Lawesson's reagent / benzene / a.) 10 deg C, 5 min, b.) up to room temp., 10 min

2: 29 percent / hydroquinone / benzene / a.) room temp., 2 h, b.) 40 deg C, 2 h

With Lawessons reagent; hydroquinone; In benzene;

DOI:10.1055/s-1991-26513

upstream raw materials:

1-(4-chloro-phenyl)-2,2-dihydroxy-ethanone

N,N-Dimethylhydrazine

Downstream raw materials:

1-(4-Chloro-phenyl)-2-(dimethyl-hydrazono)-ethanethione

6-(4-Chloro-phenyl)-2H-[1,4]thiazine-3-carbaldehyde

1-[6-(4-Chloro-phenyl)-2H-[1,4]thiazin-3-yl]-ethanone

1-[6-(4-Chloro-phenyl)-4-dimethylamino-3,4-dihydro-2H-[1,4]thiazin-3-yl]-ethanone