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![(5S,5aS,8aS)-5-(N',N'-Dimethyl-hydrazino)-1,3,7-trimethyl-5,5a,8a,9-tetrahydro-1H-pyrrolo[3,4-g]quinazoline-2,4,6,8-tetraone](/Databaselist/images/loading.webp)
57-14-7Relevant academic research and scientific papers
POLAROGRAPHIC AND VOLTAMMETRIC DETERMINATION OF 1-(2'-NITROPHENYL)-3,3-DIMETHYLTRIAZENE
Barek, Jiri,Drevinkova, Dana,Zima, Jiri
, p. 2021 - 2038 (1993)
The polarographic behaviour of 1-(2'-nitrophenyl)-3,3-dimethyltriazene in a mixed aqueos-methanolic solvent was investigated by tast polarography, differential pulse polarography, and fast scan differential pulse voltammetry at a hanging mercury drop electrode.A mechanism is suggested for the reduction of the compound investigated.The optimum conditions were found for the determination of this analyte by tast polarography over the concentration region of 100 to 2 μmol l-1 and by differential pulse polarography or fast scan differential pulse voltammetry at a hanging mercury drop electrode over the region of 100 to 0.2 μmol l-1.Additional sensitivity increase in the last-mentioned technique was achieved by adsorptive accumulation of analyte on the ahnging mercury drop surfase, owing to which the concentration region was depressed to 0.1 - 0.02 μmol l-1.
Catalytic Proton Coupled Electron Transfer from Metal Hydrides to Titanocene Amides, Hydrazides and Imides: Determination of Thermodynamic Parameters Relevant to Nitrogen Fixation
Pappas, Iraklis,Chirik, Paul J.
, p. 13379 - 13389 (2016)
The hydrogenolysis of titanium-nitrogen bonds in a series of bis(cyclopentadienyl) titanium amides, hydrazides and imides by proton coupled electron transfer (PCET) is described. Twelve different N-H bond dissociation free energies (BDFEs) among the various nitrogen-containing ligands were measured or calculated, and effects of metal oxidation state and N-ligand substituent were determined. Two metal hydride complexes, (η5-C5Me5)(py-Ph)Rh-H (py-Ph = 2-pyridylphenyl, [Rh]-H) and (η5-C5R5)(CO)3Cr-H ([Cr]R-H, R= H, Me) were evaluated for formal H atom transfer reactivity and were selected due to their relatively weak M-H bond strengths yet ability to activate and cleave molecular hydrogen. Despite comparable M-H BDFEs, disparate reactivity between the two compounds was observed and was traced to the vastly different acidities of the M-H bonds and overall redox potentials of the molecules. With [Rh]-H, catalytic syntheses of ammonia, silylamine and N,N-dimethylhydrazine have been accomplished from the corresponding titanium(IV) complex using H2 as the stoichiometric H atom source. The data presented in this study provides the thermochemical foundation for the synthesis of NH3 by proton coupled electron transfer at a well-defined transition metal center.
Preparation method of PI3K inhibitor
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Paragraph 0062; 0065-0066, (2020/08/02)
The invention provides a preparation method of a PI3K inhibitor. The PI3K inhibitor is (S)-2-[1-(9H-purine-6-ylamino) ethyl]-3-(dimethylamino)-5-fluoroquinazoline-4 (3H)-ketone, and the structural formula of the PI3K inhibitor is shown in the specification. The method comprises three steps of reactions. The method has the advantages of simple reaction steps, mild reaction conditions, indiscriminate application of the solvent, economy and environmental protection. The PI3K inhibitor is subjected to optical purification and salifying crystallization refining through organic acid resolution and has simplicity in operation, improved yield, low cost and more stable batch-to-batch quality in comparison with present silica gel column chromatography and preparation separation and is suitable for industrial production.
Ammonia-dimethylchloramine system: Kinetic approach in an aqueous medium and comparison with the mechanism involving liquid ammonia
Stephan,Pasquet,Elkhatib,Goutelle,Delalu
, p. 340 - 351 (2008/09/21)
After an exhaustive study of the system ammonia-dimethylchloramine in liquid ammonia, it was interesting to compare the reactivity of this system in liquid ammonia with the same system in an aqueous medium. Dimethylchloramine prepared in a pure state undergoes dehydrohalogenation in an alkaline medium: the principal products formed are N-methylmethanimine, 1,3,5- trimethylhexahydrotriazine, formaldehyde, and methylamine. The kinetics of this reaction was studied by UV, GC, and HPLC as a function of temperature, initial concentrations of sodium hydroxide, and chlorinated derivative. The reaction is of the second order and obeys an E2 mechanism (k1 =4.2 × 10-5 M-1 s-1, ΔH# = 82 kJ mol-1, ΔS# = -59 J mol-1 K-1) The oxidation of unsymmetrical dimethylhydrazine by dimethylchloramine involves two consecutive processes. The first step follows a first-order law with respect to haloamine and hydrazine, leading to the formation of an aminonitrene intermediate (k2 = 150 × 10-5 M-1 s -1). The second step corresponds to the conversion of aminonitrene into formaldehyde dimethylhydrazone at pH 13). This reaction follows a first-order law (k3 = 23.5 × 10-5 s-1) The dimethylchloramine-ammonia interaction corresponds to a SN2 bimoiecular mechanism (k4 = 0.9 × 10-5 M-1 s -1, pH 13, and T =25°C). The kinetic model formulated on the basis of the above reactions shows that the formation of the hydrazine in an aqueous medium comes under strong competition from the dehydrohalogenation of dimethylchloramine and the oxidation of the hydrazine formed by the original chlorinated derivative. A global model that explains the mechanisms both in an anhydrous and in an aqueous medium was elaborated.
Interaction between substituted chloramines and liquid ammonia using the indirect Raschig process
Stephan, Juliette,Berthet, Jacques,Goutelle, Veronique,Pasquet, Veronique,Delalu, Henri
, p. 808 - 812 (2007/10/03)
In this paper, different hydrazines are synthesised by the indirect Raschig process. This consists of introducing a substituted chloramine (R 1R2NCl) into liquid ammonia under pressure to obtain the corresponding hydrazine (R1R2NNH2). The experimental results, in disagreement with those reported in the literature, lead us to propose a new mechanistic scheme involving a chlorine transfer reaction. Thus, the formation of chloramine (NH2Cl) and the amine (R1R2NH) occurs first. Chloramine reacts immediately with the substituted amine, in agreement with the direct Raschig process, to produce the hydrazine. Under these conditions, the nature of the hydrazine is kinetically controlled by the excess amine. It is then possible to synthesise different hydrazines from the same substituted chloramine. This mechanism is validated by the following syntheses: unsymmetric dimethylhydrazine (UDMH), N-aminopiperidine (NAPP) and N-amino 3-azabicyclo[3.3.0]octane (NAZA).
Process for the preparation of metal nitride coatings from single source precursors and precursors suitable therefor
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, (2008/06/13)
Metal nitride coatings are deposited effectively by the decomposition of single source metal imido-amido-amine precursors prepared by the reaction of a pentavalent metal halide with a primary amine or hydrazine. With hydrazine-derived precursors, TaN coatings may be deposited at temperatures as low as 400 degrees Celcius or lower.
Nodulisporic acid derivatives
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, (2008/06/13)
The present invention relates to novel nodulosporic acid derivatives, which are acaricidal, antiparasitic, insecticidal and anthelmintic agents.
POLAROGRAPHIC AND VOLTAMMETRIC DETERMINATION OF 1-(2'-CARBAMOYLPHENYL)-3,3-DIMETHYLTRIAZENE
Barek, Jiri,Toubar, Safa,Zima, Jiri
, p. 2073 - 2081 (2007/10/02)
A study was carried out of the polarographic behaviour of the genotoxic substance 1-(2'-carbamoylphenyl)-3,3-dimethyltriazene and optimum conditions were found for its determination by tast polarography or differential pulse polarography at a static mercury drop electrode and by fast scan differential pulse voltammetry at a hanging mercury drop electrode in the concentration range 1 * 10-4 -2 * 10-7 mol l-1.The sensitivity of the determination can be further improved through adsorptive accumulation of the test substance on the surface of the hanging mercury drop electrode; five-minute accumulation in unstirred solution permits determination in the concentration range (2-10 * 10-8 mol l-1 and two-minute accumulation in stirred solution allows determination in the range (2-10) * 10-9) mol l-1.
CYCLIC HYDROCARBONS WITH AN AMINOALKYL SIDECHAIN
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, (2008/06/13)
Provided are cyclic hydrocarbons of Formula I with an aminoalkyl sidechain that are useful for treating phospholipase A2 mediated conditions, diabetes, and obesity.