2-Acetamido-5-methylthiazole

Base Information

• Chemical Name: 2-Acetamido-5-methylthiazole
• CAS No.: 61996-32-5
• Molecular Formula: C6H8N2OS
• Molecular Weight: 156.2055
• Hs Code.: 2934100090
• NSC Number: 170683
• DSSTox Substance ID: DTXSID20305403
• Nikkaji Number: J502.319J
• Wikidata: Q82052028
• ChEMBL ID: CHEMBL3770595
• Mol file: 61996-32-5.mol

Synonyms:2-Acetamido-5-methylthiazole;61996-32-5;N-(5-Methylthiazol-2-yl)acetamide;N-(5-methyl-1,3-thiazol-2-yl)acetamide;N-(5-methyl-thiazol-2-yl)-acetamide;NSC170683;SCHEMBL2175131;CHEMBL3770595;DTXSID20305403;MFCD18801061;AKOS008918774;NSC-170683;AM101037;BS-29154;CS-0209959

Chemical Property of 2-Acetamido-5-methylthiazole

Chemical Property:

• Melting Point: >225°C (dec.)
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 70.23000
• Density: 1.285g/cm³
• LogP: 1.48290
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Very Slightly, Heated)
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 156.03573406
• Heavy Atom Count: 10
• Complexity: 140

Purity/Quality:

99%min ^*data from raw suppliers

2-Acetamido-5-methylthiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN=C(S1)NC(=O)C

Technology Process of 2-Acetamido-5-methylthiazole

There total 4 articles about 2-Acetamido-5-methylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

5-methyl-2-thiazol-2-amine (7305-71-7) + acetyl chloride (75-36-5) → N-(5-methylthiazol-2-yl)acetamide (61996-32-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 - 20 ℃; for 2h;

DOI:10.1021/acs.jmedchem.5b01517

Reference yield:

5-methyl-2-thiazol-2-amine (7305-71-7) + acetic anhydride (108-24-7) → N-(5-methylthiazol-2-yl)acetamide (61996-32-5)

Guidance literature:

With acetic acid;

DOI:10.1139/v53-118

Reference yield:

5-methyl-2-nitrothiazole + acetic anhydride (108-24-7) → N-(5-methylthiazol-2-yl)acetamide (61996-32-5)

Guidance literature:

With nickel; Hydrogenation;

DOI:10.1002/hlca.19500330214

upstream raw materials:

5-methyl-2-thiazol-2-amine

acetic anhydride

1-bromo-1-nitropropan-2-one

acetyl chloride

Refernces

• 1、 Schiedel, Matthias,Rumpf, Tobias,Karaman, Berin,Lehotzky, Attila,Oláh, Judit,Gerhardt, Stefan,Ovádi, Judit,Sippl, Wolfgang,Einsle, Oliver,Jung, Manfred. "Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study". . p. 1599 - 1612. Retrieved 2016/03/05.
• 2、 -. "QUINOLINE DERIVATIVES". Page/Page column 163. . Retrieved 2008/06/13.