3-Morpholinophenol

Base Information

• Chemical Name: 3-Morpholinophenol
• CAS No.: 27292-49-5
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.219
• Hs Code.: 2934999090
• European Community (EC) Number: 608-075-7
• DSSTox Substance ID: DTXSID30181735
• Nikkaji Number: J1.966.305A
• Wikidata: Q83052351
• Mol file: 27292-49-5.mol

Synonyms:3-Morpholinophenol;27292-49-5;3-morpholin-4-ylphenol;3-(morpholin-4-yl)phenol;Phenol, 3-(4-morpholinyl)-;3-(4-morpholinyl)phenol;3-Morpholin-4-yl-phenol;m-Morpholinophenol;3-morpholinylphenol;3-morpholino phenol;3-morpholinyl-phenol;3-(4-morpholino)phenol;3-(4-morpholinyl)-phenol;SCHEMBL226009;4-(3-Hydroxyphenyl)morpholine;3-Morpholinophenol, AldrichCPR;DTXSID30181735;AMY32879;PHENOL,3-(4-MORPHOLINYL)-;AR3098;MFCD00051675;AKOS005067627;PS-4694;SDCCGMLS-0066266.P001;CS-0044986;FT-0613694;EN300-1723688;A913276;1,1-Bicyclohexyl,4-ethenyl-4-propyl-,(trans,trans)-

Chemical Property of 3-Morpholinophenol

Chemical Property:

• Vapor Pressure: 9.18E-06mmHg at 25°C
• Melting Point: 136 °C
• Refractive Index: 1.574
• Boiling Point: 362.6 °C at 760 mmHg
• PKA: 10.27±0.10(Predicted)
• Flash Point: 173.1 °C
• PSA: 32.70000
• Density: 1.185 g/cm³
• LogP: 1.29380
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 179.094628657
• Heavy Atom Count: 13
• Complexity: 157

Purity/Quality:

99% ^*data from raw suppliers

3-Morpholinophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C2=CC(=CC=C2)O

Technology Process of 3-Morpholinophenol

There total 12 articles about 3-Morpholinophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

morpholine (110-91-8,99108-56-2) + 3-monochlorophenol (108-43-0) → 3-(4-morpholino)phenol (27292-49-5)

Guidance literature:

With lithium hexamethyldisilazane; 2,8,9-tris(2-methylpropyl)-2,5,8,9-tetraaza-1-phosphabicyclo[3.3.3]undecane; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; toluene; at 100 ℃; for 29h;

DOI:10.1002/adsc.200404005

Reference yield: 95.7%

3-morpholine-4-ylaniline (159724-40-0) → 3-(4-morpholino)phenol (27292-49-5)

Guidance literature:

With sulfuric acid; sodium nitrite; In water; at 3 - 65 ℃; for 21h;

Reference yield: 83.0%

3-morpholin-4-yl-cyclohex-2-enone (16179-67-2) → 3-(4-morpholino)phenol (27292-49-5)

Guidance literature:

With 5 mol% Pd/C; hydrogen; potassium carbonate; In N,N-dimethyl acetamide; at 150 ℃; for 12h; under 608.041 Torr;

DOI:10.1039/c5sc01044f

upstream raw materials:

morpholine

recorcinol

3-oxa-1,5-dichloropentane

m-Hydroxyaniline

Downstream raw materials:

μ-imido-dicarbonic acid ethyl ester 3-morpholin-4-yl-phenyl ester

1-morpholin-4-yl-3-phenylcarbamoyloxy-benzene

5-morpholin-4-yl-2-nitroso-phenol

2-chloro-1-(2-hydroxy-4-morpholin-4-yl-phenyl)-ethanone

Refernces

• 1、 Han, Hai-Hao,Huang, Jia-Min,Li, Jia,Sun, Yi-Hang,Wang, Cheng-Yun,Zang, Yi. "A long-wavelength fluorescent probe with a large Stokes shift for lysosome-targeted imaging of Cys and GSH". . . Retrieved 2021.
• 2、 -. "Inter-alkane amidogen phenolic synthetic method (by machine translation)". Paragraph 0029. . Retrieved 2019/01/23.