1,4-Dioxa-7-azaspiro[4.4]nonane

Base Information

• Chemical Name: 1,4-Dioxa-7-azaspiro[4.4]nonane
• CAS No.: 176-33-0
• Molecular Formula: C6H11NO2
• Molecular Weight: 129.159
• European Community (EC) Number: 823-112-9
• DSSTox Substance ID: DTXSID90569419
• Wikidata: Q82456568
• Mol file: 176-33-0.mol

Synonyms:1,4-dioxa-7-azaspiro[4.4]nonane;176-33-0;1,4-Dioxa-7-aza-spiro[4.4]nonane;MFCD09833560;SCHEMBL824614;DTXSID90569419;JTOUWLZSXWMCSH-UHFFFAOYSA-N;AKOS004911111;AT11217;SB34294;BS-35781;SY180174;CS-0217019;EN300-66175;1,4-Dioxa-7-azaspiro[4.4]nonane, AldrichCPR;A846185;Z1037337340

Chemical Property of 1,4-Dioxa-7-azaspiro[4.4]nonane

Chemical Property:

• Vapor Pressure: 0.221mmHg at 25°C
• Refractive Index: 1.501
• Boiling Point: 206.714 °C at 760 mmHg
• Flash Point: 72 °C
• PSA: 30.49000
• Density: 1.161 g/cm³
• LogP: 0.05160
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 129.078978594
• Heavy Atom Count: 9
• Complexity: 110

Purity/Quality:

99% ^*data from raw suppliers

1,4-Dioxa-7-azaspiro[4.4]nonane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCC12OCCO2

Technology Process of 1,4-Dioxa-7-azaspiro[4.4]nonane

There total 2 articles about 1,4-Dioxa-7-azaspiro[4.4]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(benzyloxycarbonyl)-7-aza-1,4-dioxospiro<4.4>nonane (139524-57-5) → 1,4-dioxa-6-azaspiro[4.4]nonane (176-33-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 1.5h; under 3102.97 Torr;

DOI:10.1021/jm0604528

Reference yield: 44.0%

N-ethoxycarbonyl-3-pyrrolidinone ethylene ketal (14891-11-3) → 1,4-dioxa-6-azaspiro[4.4]nonane (176-33-0)

Guidance literature:

With potassium hydroxide; In water; for 16h; Reflux;

DOI:10.1021/jm800259e

Reference yield: 96.0%

N-(3,4-dimethoxyphenyl)-O-phenyl carbamate (65141-27-7) + 1,4-dioxa-6-azaspiro[4.4]nonane (176-33-0) → 1,4-dioxa-7-aza-spiro[4.4]nonane-7-carboxylic acid (3,4-dimethoxy-phenyl)-amide

Guidance literature:

In methanol; for 0.25h; microwave irradiation;

DOI:10.1055/s-2005-923584

upstream raw materials:

N-ethoxycarbonyl-3-pyrrolidinone ethylene ketal

N-(benzyloxycarbonyl)-7-aza-1,4-dioxospiro<4.4>nonane

Downstream raw materials:

2-(1,4-dioxa-7-aza-spiro[4.4]nonane-7-carbonyl)-benzoic acid methyl ester

1-(2,4-Difluoro-phenyl)-7-(1,4-dioxa-7-aza-spiro[4.4]non-7-yl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

1-(2,4-Difluoro-phenyl)-7-(1,4-dioxa-7-aza-spiro[4.4]non-7-yl)-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester

7-(2-formyl-benzoyl)-1,4-dioxa-7-aza-spiro[4.4]nonane

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