3-Quinolinecarboxylic acid, 1-(2,4-difluorophenyl)-7-(1,4-dioxa-7-azaspiro[4.4]non-7-yl)-6-fluoro-1,4 -dihydro-4-oxo-, ethyl ester

Base Information Edit

Chemical Name:3-Quinolinecarboxylic acid, 1-(2,4-difluorophenyl)-7-(1,4-dioxa-7-azaspiro[4.4]non-7-yl)-6-fluoro-1,4 -dihydro-4-oxo-, ethyl ester
CAS No.:139524-59-7
Molecular Formula:C24H21F3N2O5
Molecular Weight:474.436
Hs Code.:
Mol file:139524-59-7.mol

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Chemical Property of 3-Quinolinecarboxylic acid, 1-(2,4-difluorophenyl)-7-(1,4-dioxa-7-azaspiro[4.4]non-7-yl)-6-fluoro-1,4 -dihydro-4-oxo-, ethyl ester Edit

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Technology Process of 3-Quinolinecarboxylic acid, 1-(2,4-difluorophenyl)-7-(1,4-dioxa-7-azaspiro[4.4]non-7-yl)-6-fluoro-1,4 -dihydro-4-oxo-, ethyl ester

There total 2 articles about 3-Quinolinecarboxylic acid, 1-(2,4-difluorophenyl)-7-(1,4-dioxa-7-azaspiro[4.4]non-7-yl)-6-fluoro-1,4 -dihydro-4-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 139524-57-5
N-(benzyloxycarbonyl)-7-aza-1,4-dioxospiro<4.4>nonane

: 139524-59-7
1-(2,4-Difluoro-phenyl)-7-(1,4-dioxa-7-aza-spiro[4.4]non-7-yl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 31 percent / H₂ / 20percent Pd/C / ethyl acetate; methanol / 24 h / Ambient temperature

2: Et₃N / pyridine / 24 h / 45 °C

With hydrogen; triethylamine; palladium on activated charcoal; In pyridine; methanol; ethyl acetate;