6-Hydroxyetodolac

Base Information

Chemical Name:6-Hydroxyetodolac
CAS No.:101901-06-8
Molecular Formula:C₁₇H₂₁NO₄
Molecular Weight:303.358
Hs Code.:
UNII:JCH8N6A1AY
ChEMBL ID:CHEMBL873
Nikkaji Number:J357.715E
Wikidata:Q27281437
Mol file:101901-06-8.mol

Synonyms:6-HYDROXYETODOLAC;6-Hydroxy Etodolac;101901-06-8;RAK-901;JCH8N6A1AY;2-(1,8-diethyl-6-hydroxy-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)acetic acid;1,8-Diethyl-1,3,4,9-tetrahydro-6-hydroxypyrano(3,4-b)indole-1-acetic acid;1,8-Diethyl-1,3,4,9-tetrahydro-6-hydroxypyrano[3,4-b]indole-1-acetic Acid;Pyrano[3,4-b]indole-1-acetic acid, 1,8-diethyl-1,3,4,9-tetrahydro-6-hydroxy-;UNII-JCH8N6A1AY;CCRIS 5403;PYRANO(3,4-B)INDOLE-1-ACETIC ACID, 1,8-DIETHYL-1,3,4,9-TETRAHYDRO-6-HYDROXY-;BRN 6430398;CHEMBL873;SCHEMBL9142535;AKOS030255416;Pyrano(3,4-b)indole-1-acetic acid, 1,3,4,9-tetrahydro-1,8-diethyl-6-hydroxy-;PD150805;NS00116645;J-000513;Q27281437;2-(1,8-Diethyl-6-hydroxy-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid

Suppliers and Price of 6-Hydroxyetodolac

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-HydroxyEtodolac
25mg
$ 1020.00

American Custom Chemicals Corporation
6-HYDROXY ETODOLAC 95.00%
50MG
$ 1871.10

American Custom Chemicals Corporation
6-HYDROXY ETODOLAC 95.00%
5MG
$ 774.40

Total 8 raw suppliers

Chemical Property of 6-Hydroxyetodolac

Chemical Property:

Vapor Pressure:5.11E-11mmHg at 25°C
Melting Point:157-159oC
Boiling Point:509.9°Cat760mmHg
Flash Point:262.2°C
PSA：82.55000
Density:1.237g/cm³
LogP:3.08860
Storage Temp.:Refrigerator
Solubility.:Dichloromethane (Slightly, Heated), DMSO (Slightly), Methanol (Slightly, Sonicat
XLogP3:2.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:303.14705815
Heavy Atom Count:22
Complexity:429

Purity/Quality:

99% ^*data from raw suppliers

6-HydroxyEtodolac ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1=C2C(=CC(=C1)O)C3=C(N2)C(OCC3)(CC)CC(=O)O
Uses 6-Hydroxy Etodolac is an Etodolac (E933100) metabolite.

Technology Process of 6-Hydroxyetodolac

There total 4 articles about 6-Hydroxyetodolac which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 114720-21-7
6-hydroxyetodolac methyl ester

: 101901-06-8
6-hydroxyetodolac

Guidance literature:: With potassium hydroxide; In methanol; water; for 5h; Heating;
DOI:10.1021/jm00117a009

Reference yield:

: 41340-36-7
7-ethyl-2-(1H-indol-3-yl)ethan-1-ol

: 101901-06-8
6-hydroxyetodolac

Guidance literature:: Multi-step reaction with 4 steps

1: 48 percent / NaBH₄ / trifluoroacetic acid / 1 h

2: 1.) potassium nitrosodisulfonate / 1.) pH 7 buffer, Me₂CO, 10 min, 2.) room temperature, overnight

3: 66 percent / boron trifluoride etherate / tetrahydrofuran; CH₂Cl₂ / 28 h / Ambient temperature

4: 85 percent / KOH / methanol; H₂O / 5 h / Heating

With potassium hydroxide; sodium tetrahydroborate; potassiuim nitrosodisulfonate; boron trifluoride diethyl etherate; In tetrahydrofuran; methanol; dichloromethane; water; trifluoroacetic acid;
DOI:10.1021/jm00117a009

Reference yield:

: 114720-06-8
7-ethyl-5-hydroxytryptophol

: 101901-06-8
6-hydroxyetodolac

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / boron trifluoride etherate / tetrahydrofuran; CH₂Cl₂ / 28 h / Ambient temperature

2: 85 percent / KOH / methanol; H₂O / 5 h / Heating

With potassium hydroxide; boron trifluoride diethyl etherate; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm00117a009