2,7-Dichloro-4-methylquinoline

Base Information

• Chemical Name: 2,7-Dichloro-4-methylquinoline
• CAS No.: 59666-16-9
• Molecular Formula: C10H7 Cl2 N
• Molecular Weight: 212.078
• Hs Code.: 2933499090
• European Community (EC) Number: 261-847-1
• DSSTox Substance ID: DTXSID4069347
• Nikkaji Number: J298.203J
• Wikidata: Q81996204
• Mol file: 59666-16-9.mol

Synonyms:2,7-Dichloro-4-methylquinoline;59666-16-9;EINECS 261-847-1;Quinoline, 2,7-dichloro-4-methyl-;SCHEMBL8936155;DTXSID4069347;MFCD01540827;AKOS000600114;BP-11246;2,7-Dichloro-4-methylquinoline, AldrichCPR;CS-0208436

Chemical Property of 2,7-Dichloro-4-methylquinoline

Chemical Property:

• Vapor Pressure: 0.000396mmHg at 25°C
• Boiling Point: 327°C at 760 mmHg
• Flash Point: 181.5°C
• PSA: 12.89000
• Density: 1.351g/cm³
• LogP: 3.85000
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 210.9955546
• Heavy Atom Count: 13
• Complexity: 186

Purity/Quality:

98% ^*data from raw suppliers

2,7-Dichloro-4-methylquinoline ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC2=C1C=CC(=C2)Cl)Cl

Technology Process of 2,7-Dichloro-4-methylquinoline

There total 3 articles about 2,7-Dichloro-4-methylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-chloro-4-methyl-1,2-dihydroquinolin-2-one (2540-09-2) → 2,7-dichloro-4-methyl-quinoline (59666-16-9)

Guidance literature:

In trichlorophosphate;

Reference yield:

→ 2,7-dichloro-4-methyl-quinoline (59666-16-9)

Guidance literature:

With trichlorophosphate;

Reference yield:

3-chloro-aniline (108-42-9) → 2,7-dichloro-4-methyl-quinoline (59666-16-9)

Guidance literature:

Multi-step reaction with 2 steps

1: concentrated H₂ SO₄; toluene

2: trichlorophosphate

In concentrated H₂ SO₄; toluene; trichlorophosphate;

upstream raw materials:

7-chloro-4-methyl-1,2-dihydroquinolin-2-one

3-chloro-aniline

Downstream raw materials:

7-chloro-4-methyl-quinoline-2-thiol

1-[4-(7-Chloro-4-methyl-quinolin-2-ylamino)-phenyl]-ethanone

Refernces