4-amino-5-chloro-2-ethoxy-N-((2-morpholinyl)methyl)benzamide

Base Information

• Chemical Name: 4-amino-5-chloro-2-ethoxy-N-((2-morpholinyl)methyl)benzamide
• CAS No.: 152013-26-8
• Molecular Formula: C14H20 Cl N3 O3
• Molecular Weight: 313.784
• Mol file: 152013-26-8.mol

Synonyms:Benzamide,4-amino-5-chloro-2-ethoxy-N-(2-morpholinylmethyl)-, (?à)-; 4-Amino-5-chloro-2-ethoxy-N-[(2-morpholinyl)methyl]benzamide

Chemical Property of 4-amino-5-chloro-2-ethoxy-N-((2-morpholinyl)methyl)benzamide

Chemical Property:

• Vapor Pressure: 2.71E-09mmHg at 25°C
• Melting Point: 137-140°C
• Boiling Point: 477.8°Cat760mmHg
• PKA: 13.52±0.46(Predicted)
• Flash Point: 242.8°C
• PSA: 85.61000
• Density: 1.234g/cm³
• LogP: 2.34000
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Very Slightly)

Purity/Quality:

97% ^*data from raw suppliers

Des-4-fluorobenzyl Mosapride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: The major metabolite of Mosapride (M731000).

Technology Process of 4-amino-5-chloro-2-ethoxy-N-((2-morpholinyl)methyl)benzamide

There total 2 articles about 4-amino-5-chloro-2-ethoxy-N-((2-morpholinyl)methyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-amino-5-chloro-2-ethoxybenzoic acid (108282-38-8) + 1-morpholin-2-ylmethanamine (116143-27-2) → Des-4-fluorobenzyl Mosapride (152013-26-8)

Guidance literature:

1-morpholin-2-ylmethanamine; With triethylamine; isobutyl chloroformate; In dichloromethane; at -10 ℃; for 0.166667h;

4-amino-5-chloro-2-ethoxybenzoic acid; In dichloromethane; at -10 - 20 ℃; for 4h;

Reference yield:

4-amino-5-chloro-2-ethoxy-N-(morpholin-2-ylmethyl)benzamide dihydrochloride → Des-4-fluorobenzyl Mosapride (152013-26-8)

Guidance literature:

With sodium hydrogencarbonate; In water;

Reference yield:

(4-fluorophenyl)(2H)formaldehyde (63462-94-2) + Des-4-fluorobenzyl Mosapride (152013-26-8) → 4-amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)morpholin-2-yl)methyl-d2)benzamide (1071809-39-6)

Guidance literature:

(4-fluorophenyl)(²H)formaldehyde; Des-4-fluorobenzyl Mosapride; In dichloromethane; at 20 ℃; for 0.5h;

With deuterated sodium cyanoborohydride; In dichloromethane; at 20 ℃;

With water; sodium hydrogencarbonate; In dichloromethane;

upstream raw materials:

4-amino-5-chloro-2-ethoxybenzoic acid

1-morpholin-2-ylmethanamine

Downstream raw materials:

4-amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)morpholin-2-yl)methyl-d2)benzamide

4-amino-5-chloro-2-ethoxy-N-((4-(4-fluoro-2,3,5,6-d4-benzyl-)morpholin-2-yl)methyl-d2)benzamide

4-amino-5-chloro-2-ethoxy-N-[{4-[(1-(1-pyrrolidinecarbonyl)-4-piperidinyl)methyl]-2-morpholinyl}-methyl]benzamide